Objective: To observe the clinical efficacy and safety of desloratadine citrate disodium in the treatment of allergic rhinitis (AR). Methods: 200 patients with AR treated at otorhinolaryngology department of Sichuan Provincial People’s Hospital from January, 2012 to October, 2014 were selected for this study. They were randomly divided into therapeutic group and control group with 100 patients ...

Chronic metabolic acidosis increases proximal tubular citrate uptake and metabolism. The present study addressed the effect of chronic metabolic acidosis on a cytosolic enzyme of citrate metabolism, ATP citrate lyase. Chronic metabolic acidosis caused hypocitraturia in rats and increased renal cortical ATP citrate lyase activity by 67% after 7 d. Renal cortical ATP citrate lyase protein abundan...

The total and ultrafiltrable citrate of serum were measured in healthy controls, and in patients with calcium-containing kidney stones classified into the various calciuria types (normocalciuria, renal, absorptive, resorptive hypercalciuria). The total citrate in two subgroups (normocalciuria, renal hypercalciuria) was significantly higher than in controls. Two independent analyses showed a mea...

Chronic metabolic acidosis increases proximal tubular citrate uptake and metabolism. The present study addressed the effect of chronic metabolic acidosis on a cytosolic enzyme of citrate metabolism, ATP citrate lyase. Chronic metabolic acidosis caused hypocitraturia in rats and increased renal cortical ATP citrate lyase activity by 67% after 7 d. Renal cortical ATP citrate lyase protein abundan...

A simple and inexpensive, single step synthesis of silver nanoparticles was achieved using sodium citrate both as a reducing and capping agent. Silver nanoparticles were synthesized by injecting sodium citrate solution into the solution of silver nitrate at high temperature. The synthetic process was carried out in aqueous solution, making the method versatile and ecofriendly. The synthesized s...

The mechanism and energetics of citrate transport in Leuconostoc oenos were investigated. Resting cells of L. oenos generate both a membrane potential (delta psi) and a pH gradient (delta pH) upon addition of citrate. After a lag time, the internal alkalinization is followed by a continuous alkalinization of the external medium, demonstrating the involvement of proton-consuming reactions in the...

A longevity gene called Indy (for 'I'm not dead yet'), with similarity to mammalian genes encoding sodium-dicarboxylate cotransporters, was identified in Drosophila melanogaster. Functional studies in Xenopus oocytes showed that INDY mediates the flux of dicarboxylates and citrate across the plasma membrane, but the specific transport mechanism mediated by INDY was not identified. To test wheth...

A hydrometallurgical treatment under ambient conditions was proposed in order to eliminate and recover the lead zinc contained a sample of thermal coal fly ash used produce energy. By using leaching solutions with conventional inorganic acids (HCl, HNO3, H2SO4), ferric chloride, sodium citrate, more than 90% approximately 40% were obtained. The most favorable set at 0,5 M, pH value 8 for citrat...

BACKGROUND Few treatments are available to slow the progression to renal failure in autosomal dominant polycystic kidney disease (PKD). In an animal model of PKD, the male heterozygous Han:SPRD rat, intake of a solution of potassium citrate plus citric acid (KCitr) from age one to three months prevented a decline in glomerular filtration rate (GFR). The present study tested whether this benefic...

Clostridium perfringens-associated necrotic enteritis causes significant economic losses. The objective of this study was to evaluate the effect of bismuth citrate, lactose, and organic acid on the development of necrotic enteritis in broilers. The first study was a dose response that evaluated bismuth citrate at 50, 100, or 200 ppm on bacterial intestinal colonization and lesion development as...