Helicobacter pylori is susceptible to many antimicrobials, but clinically only a few are effective. Two antimicrobials with bismuth or ranitidine or a proton pump inhibitor such as omeprazole are required to achieve a cure rate of >90% and to avoid resistance, which occurs when clarithromycin or metronidazole is the single antimicrobial used. Bismuth plus metronidazole and tetracycline is effec...

In recent years, the level of resistance of S. pneumoniae to beta-lactam and/or macrolides has increased around the world including some countries in South America. Because of this resistance, it is necessary to test the therapeutic alternatives for treating this pathogen, including the newer quinolones. This study was carried out in order to compare the in vitro activity of fluoroquinolones ga...

BACKGROUND Clarithromycin is one of the most important antibiotics for Helicobacter pylori eradication. However, 5-10% of strains are reported to be resistant. It has been shown that one point mutation in the 23S rRNA gene is associated with resistance to clarithromycin. AIMS To establish a polymerase chain reaction (PCR) system which amplifies a segment of the 23S rRNA gene containing the mu...

Introduction Helicobacter pylori (H. pylori) is causally associated with chronic gastritis, peptic ulcer and gastric cancer, a reported prevalence of 19-35%. Due to increasing antibiotic resistance, the worldwide efficacy H. eradication treatment has decreased. Aims & Methods This study aimed determine success in primary care Netherlands, as proxy measure for resistance de...

Corresponding Authors: Tanmoy Bera Department of Pharmaceutical Technology, Jadavpur University, Kolkata700032, India. E-mail: [email protected], Phone: +91 9831470041, Tele Fax: +91 3324146677. Abstract: Backgrounds and objectives: Leishmania donovani is one of the most common species responsible for visceral leishmaniasis (VL) in India, Bangladesh and Sudan. The pentavalent antimonials...

The antibiotic resistance of Helicobacter pylori (H pylori) is steadily increasing worldwide, resulting in the low efficiency of the current therapeutic approaches for eradication. In this study, we investigated the relationship between antibiotic resistances, the year of sample collection, and the ages of the infected individuals. A total of 29,034 gastric mucosa biopsy samples were randomly c...

Helicobacter pylori infection can serve as one of indications to clarithromycin prescription. H. eradication is performed commonly a treatment for diseases caused by this pathogen and conditions with an increased risk complications (precancerous changes the gastric mucosa, unspecified iron deficiency anemia, idiopathic thrombocytopenic purpura, long-term NSAIDs use, anti-platelet drugs use etc)...

Antimicrobial susceptibility testing for Helicobacter pylori is increasingly important due to resistance to the most used antimicrobials agents. Only agar dilution method is approved by CLSI, but it is difficult to perform routinely. We evaluated the reliability of E-test and disk diffusion comparing to agar dilution method on Helicobacter pylori antimicrobial susceptibility testing. Susceptibi...

Mycobacterium abscessus, which consists of the two subspecies M. abscessus subspecies abscessus and M. abscessus subspecies bolletii, can produce rough or smooth colony morphologies. Here we analyzed 50 M. abscessus isolates cultured from the respiratory specimens of 34 patients, 28 (82%) of whom had cystic fibrosis (CF), with respect to their colony morphologies and antibiotic susceptibilities...