Glycogen rich Clear cell carcinoma of the breast is a rare subtype of breast carcinoma occurring in 1.4 to 2.7 % of breast carcinoma patients. The significance of understanding this carcinoma lies in the fact that they usually have an aggressive course and an adverse prognosis. Here we present a case of 50 yearsold female with a left sided breast lump for 2 yearswhich histologically showed the ...

Investigating the expression of genes in cancer-associated immune cells (immunome) is imperative for prognosis prediction. However, evaluating the expression of immune-associated genes within cancer biopsy is subject to significant inconsistencies related to the sampling methodology. Here, we present immFocus, a method for extracting immune signals from total RNA sequencing of tumor biopsies, i...

The authors examined pathology from patients with renal cancer (RCC) treated with IL-2 to determine response rates for clear cell and variant RCC and to identify histologic features that predict response. Pathology specimens were reviewed by a single pathologist who was blinded to both the prior pathology interpretation and the therapeutic response. Findings were correlated with response to IL-...