Title: HIF2α targeted RNAi therapeutic inhibits clear cell renal cell carcinoma Authors and affiliations: So C. Wong, Weijun Cheng, Holly Hamilton, Anthony L. Nicholas, Darren H. Wakefield, Aaron Almeida, Andrei V. Blokhin, Jeffrey Carlson, Zane C. Neal, Vladimir Subbotin, Guofeng Zhang, Julia Hegge, Stephanie Bertin, Vladimir S. Trubetskoy, David B. Rozema, David L. Lewis, Steven B. Kanner 1. ...

ABSTRACT The suggestions for writing for publication given in this paper include writing with honesty, thinking clearly, considering the potential audience, sharing the article with friends, revising the article, and sending the article to the appropriate journal. Empathy for the difficulty of writing is given and illustrated with examples from Eric Hcffer, Ernest Hemingway, Art Buchwald, Chaim...

A combination of satellite data, reanalysis products and climate models are combined to monitor changes in water vapour, clear-sky radiative cooling of the atmosphere and precipitation over the period 1979-2006. Climate models are able to simulate observed increases in column integrated water vapour (CWV) with surface temperature (Ts) over the ocean. Changes in the observing system lead to spur...

correct context has taken a lot of work. Yanagida's approach to this work has been influenced by his location — starting with the choice of fission yeast. " Working on a remote island, I thought it may be better to work on a more obscure organism, " he says. And once that work was started, " we were quite happy to study these mutants in an isolated fashion. " But if the research was somewhat is...

The agricultural sector is of particular importance in the city of Bijar. Thus, the economic value perunit of water applid to the side effects of excessive groundwater resources in this area has a utmostimportance. Payment for estimation of water on a suitable production function was estimated revenueproducers. Therefore in this study to estimate the economic value of water resources in agricul...

The scattering and absorption of light by water molecules and by suspended and dissolved matter (turbidity) degrade image transmission and, thus, underwater perception. We tested the effects on visual detection of prey size and distance (affecting apparent prey size) and of low-level water turbidity in hand-reared great cormorants (Phalacrocorax carbo sinensis) diving for natural prey (fish) in...

The essential role of water in extra- and intracellular coiled coil structures of proteins is critically evaluated, and the different protein types incorporating coiled coil units are overviewed. The following subjects are discussed: i) influence of water on the formation and degradation of the coiled coil domain together with the stability of this conformer type; ii) the water's paradox iii) d...

We studied a small subarctic lake to assess the magnitude of winter respiration and the organic carbon (OC) source for this respiration. The concentration and stable isotopic composition (d13C) of dissolved inorganic carbon (DIC) accumulating in the lake water under ice was analyzed over one winter (7 months). The DIC concentration increased and the d13C of DIC decreased over time, with the gre...

UAVs and other low-altitude remote sensing platforms are proving very useful tools for remote sensing of river systems. Currently consumer grade cameras are still the most commonly used sensors for this purpose. In particular, progress is being made to obtain river bathymetry from the optical image data collected with such cameras, using the strong attenuation of light in water. No studies have...

[1] Passive microwave radiometers have a long history in the remote sensing of atmospheric liquid and water vapor. Retrievals of these quantities are sensitive to variations in pressure and temperature of the liquid and water vapor. Rather than use a statistical or climatological approach to account for the natural variability in atmospheric pressure and temperature, additional information on t...