OBJECTIVE Mutations in exon 1 of ARHGAP29, a RhoA specific GTPase have been identified in North American and Filipino subjects with nonsyndromic cleft palate and cleft lip with or without cleft palate. Since the genetic status of ARHGAP29 in Indian subjects with nonsyndromic oral clefts is not known, we designed the present study to investigate the occurrence of the above mutations in them. M...

BACKGROUND The goals of this study were to delineate the protocols employed for managing patients with cleft lip and palate deformities, delineate the challenges facing practitioners and patients, and to determine the patient and physician barriers to cleft care delivery in the region. METHODS Survey questionnaires were administered to practitioners attending the second Pan-African Congress o...

Cleft lip (cheiloschisis) and cleft palate (palatoschisis) can occur individual or together. Individuals with CLP may experience problems with feeding, speaking, hearing and social integration that can be corrected to varying degrees by surgery, dental treatment, speech therapy and psychological intervention. In India over 35,000 babies per year are affected. This review signifies the etiologic...

Facial cleft is the second most common congenital deformity. Problems of cleft can be related to esthetic, phonetics, functional insufficiency, emotional, psychological and social. Significant abnormality in nasal cartilage morphology and asymmetry of alar base and columella are associated with cleft lip and alveolar deformity. Pre Nasoalveolar molding (PNAM) is a nonsurgical method of reshapin...

Orofacial clefts, including cleft lip with or without cleft palate, are among the most common visible birth defects, occurring in 1 of every 500 – 1000 live births worldwide ( Murray, 1995 ). With a prevalence of 14.7 per 10 000 births in Australia ( Lancaster and Pedisich, 1995 ), orofacial clefts are the most frequent congenital craniofacial deformities ( Sinko et al. , 2005 ). Cleft lip and...

2. Preoperative assessment of the child with cleft lip and palate a) The presence of rhinorrhoea means surgery should be cancelled b) Bilateral cleft lip predicts difficult laryngoscopy c) Bilateral cleft lip predicts an increased risk of postoperative respiratory complications d) A history of apnoea during feeds may indicate chronic airway obstruction e) Sedative premedication is useful and pr...

OBJECTIVES This study aims to describe morphological peculiarities of maxillary and mandibular first molars in Europeans, Asians and Europeans with cleft lip and palate. MATERIAL AND METHODS Reflex microscopy was used to obtain three-dimensional morphometric landmarks from 40 models (11 Europeans and 13 Asians without cleft lip and palate, 16 Europeans with unilateral cleft lip and palate). T...

Cleft lip and palate is the one of the most common visible congenital deformities. Approximately 30% of oral clefts are syndromic and are associated with some anomalies. Global surveys have shown that the frequency of cleft lip and palate varies greatly from country to country. The present study analysed demographic and associated anomalies in children attending the high volume Smile Train cent...

Significant heterogeneity has previously been reported but with no consensus on the prevalence of dental anomalies in subjects with a cleft lip and palate (CLP), thus, the purpose of this study was to investigate the frequency of various dental anomalies in the upper dental arch in different cleft groups. Diagnostic records, i.e., panoramic, occlusal and periapical films, dental casts, and intr...