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Authors' disclosures of potential conflicts of interest are found at the end of this article. S tudies of how patients respond to treatment over time are fundamentally important to understanding how therapies influence quality of life and progression of disease during survi-vorship. When investigators examine change over time in continuous variables (e.g., patient self-reports of pain, fatigue,...

Osteoarthritis was seen as a stepchild of rheumatology until very recently. Veterinarians took an interest in it because they had racehorses and racing greyhounds to take care of, whose economic value to their owners made it worthwhile. But medicine had little to offer, especially as osteoarthritis was thought to be part of ageing, like the greying of hair, and few distinctions were made in the...

Guest Editorial I t is a very exciting time for clini-cians who are confronted with infantile hemangiomas. So much new information is now available regarding pathogenesis, epidemiology, differential diagnosis, and therapy. These aspects are reviewed in greater detail in the accompanying articles by a group of experienced scientists and clinicians, who help provide a richer and more sophisticate...

For patients with high-grade tumors infiltrating the super ficial bladder wall musculature or with tumors of any grade invading deep muscle or the perivesical space, the evidence is now quite solid that integrated treatment with irradiation and cystectomy (or a lesser resection in rare, selected cases) results in a significantly higher survival rate than does either approach alone. Several ques...

is now well established that significant interindividual variability exists in the disposition and pharmacologic effects of certain medications. Influences such as environmental exposures, nutritional status, co-morbidities, severity of disease, and concomitant medications have all been associated with heterogeneity in drug responses. In addition, the profound contribution of genetics has been ...

infection, underlying disease(s), the medical setting in which the infection occurred, the appropriateness of antibiotics prescribed, the age and sex of the patients, no increased death was associated with MRSA, although inappropriate therapy was associated with a poorer outcome. In contrast, for bone infections and mediastinitis, MRSA may increase the risk of death. The complete results of sta...

S troke and atrial fibrillation (AF) are both frequent diseases (with respective prevalence >2.5% and >1% of the adult population in developed countries) and have major medical and financial impact. The link between the 2 diseases has been long since identified; the presence of AF is independently associated with a raw 5-fold increased risk of stroke. 1 Cardiologists have learned from the Atria...

I T IS hoped that Perspectives in Nutrition will review the literature selectively, interpret it moderately and present a spectrum of ideas that will serve as a continual stimulation to nutritional research applied to medical problems. M AGNESIUM has been accepted as an essential nutrient for the rat since 1932 when Kruse, Orent and McCollum 1 induced an acute magnesium deficiency syndrome in r...

Almost ten years ago, in the spring of 2007, at the Wirral University Teaching Hospital in Wirral (UK), cytomegalo‑ virus (CMV)‑positive twins were treated at the local Neonatal Intensive Care Unit (NICU) (1). The management of this viral infection in both neonates required the collaboration of an extended scientific network in Merseyside and Manchester, including several experienced consultant...