Summary Clinical trials involving brain disorders are notoriously difficult to set up and run. Innovative ways develop effective prevention treatment strategies for central nervous system (CNS) diseases urgently needed. New approaches that likely renew or at least modify the paradigms used so far have been recently proposed. Quantitative systems pharmacology (QSP) uses mathematical computerized...

Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuremberg, Fahrstr. 17, 91054 Erlangen, Germany (J.K., H.G., K.M., M.F.F.) Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, 17487 Greifswald, Germany (M.K.) Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttg...

teicoplanin is a glycoside antibiotic which consists of five closely related glycopeptide antibiotics with similar antibacterial properties to vancomycin that were first isolated in 1976. teicoplanin is active against many gram-positive anaerobe microorganisms and is particularly potent against clostridium species. it is also active against most listeria, enterococci and staphylococci including...

home of the division will probably be a department of pharmacology, although special arrangements regarding budget, personnel, and appOintments will probably be necessary. Training in clinical pharmacology should be from 1 to 3 years. The trainee should have already received a background of clinical experience, and this may be further strengthened during his specific training in clinical pharma...

1 Division of Clinical Pharmacology, Linköping University Hospital, Linköping, Sweden 2 Division of Clinical Pharmacology, Sahlgrenska University Hospital, Göteborg, Sweden 3 Uppsala Monitoring Centre, WHO Collaborating Centre for International Drug Monitoring, Uppsala, Sweden 4 Department of Clinical Pharmacology, St Olav University Hospital, Trondheim, Norway 5 Department of Laboratory Medici...

The explosion of knowledge concerning the interplay of genetic and environmental factors determining pathophysiology and guiding therapeutic choice has altered the landscape in pediatric clinical pharmacology and pharmacy. The need for innovative research methods and design expertise for small clinical trials to be undertaken in sparse populations has been accentuated. At the same time, shortfa...

INTRODUCTION The need for valid, reliable, and objective tools has always been emphasized in studies related to the clinical assessment of nursing students. The aims of this study were to develop and assess the validity and reliability of the tools used to evaluate the clinical pharmacology unit. METHODS This study was a methodological one, conducted in 2016. An item pool was developed based ...

Quantitative pharmacology (QP) applications in translational medicine, drug-development, and therapeutic use were crowd-sourced by the ASCPT Impact and Influence initiative. Highlighted QP case studies demonstrated faster access to innovative therapies for patients through 1) rational dose selection for pivotal trials; 2) reduced trial-burden for vulnerable populations; or 3) simplified posolog...

number of new drugs which have appeared during the last three years have been included and the author has been very wise in exercising a judicious caution in their selection. The sulphanilamide group of drugs which, is still in an experimental stage has received adequate attention. The book has been well written and brings out with great clarity the really important actions and therapeutic uses...

Postgraduate courses in clinical pharmacology are important for dentists to be updated on drug therapy and information related to their clinical practice, as well as knowledge of relevant adverse effects and interactions. A traditional approach with classroom delivery as the only method to teaching and learning has shortcomings regarding flexibility, individual learning preferences, and problem...