PURPOSE To correlate the differentially expressed miRNAs with clinico-pathological features in uveal melanoma (UM) tumors harbouring chromosomal 3 aberrations among South Asian Indian cohort. METHODS Based on chromosomal 3 aberration, UM (n = 86) were grouped into monosomy 3 (M3; n = 51) and disomy 3 (D3; n = 35) by chromogenic in-situ hybridisation (CISH). The clinico-pathological features w...

RhoA protein is over-expressed in breast cancer and other solid tumors and has been used in tumor biopsies as a quantitative tumor marker for progression, stage and prognosis in molecular detection strategies. Measuring protein markers in plasma or blood cells is preferred to tumor biopsies as it represents a minimally invasive, repeatable measurement that can be followed over time. In this stu...

BACKGROUND Cancers of the oral cavity are primarily oral squamous cell carcinomas (OSCCs). Many of the OSCCs present at late stages with an exceptionally poor prognosis. A probable limitation in management of patients with OSCC lies in the insufficient knowledge pertaining to the linkage between copy number alterations in OSCC and oral tumourigenesis thereby resulting in an inability to deliver...

OBJECTIVES To systematize the clinico-radiological symptoms and course of bisphosphonate-related osteonecrosis of jaw bone and toevaluate the diagnostic potential of various radiological techniques to detect mild osteonecrosis in each stage of the disease. MATERIAL AND METHODS The sample consisted of 22 patients previously diagnosed with extraoral malignant disease. Diagnosis was based on a c...

Background: Distinguishing between sub-clinical and aggressive forms of prostate cancer is difficult due to the heterogeneity of the disease. It is, however, important to identify aggressive forms to guide proper treatment. This study compared gene expression profiles in cancer cells from hereditary and sporadic prostate cancer cases and attempted to correlate differentially regulated genes wit...

Objetivo: O objetivo desse relato é descrever um caso raro de sinusite fúngica invasiva crônica que evoluiu com meningite causando síndrome hipertensão craniana e tetraplegia, demonstrando por meio deste, a importância da realização uma investigação diagnóstica mais aprofundada mesmo em doença considerada diagnóstico clinico. Assim, evitar o retardo terapia adequada.

Pé diabético é uma série de alterações que podem ocorrer nos pés pessoas com diabetes não controlado. Infecções ou problemas na circulação dos membros inferiores estão entre as compliações mais comuns, provocando o surgimento feridas cicatrizam e infecções pés. Apresenta-se aqui caso clinico paciente 53 anos, sexo masculino lesão em pé.

Intracerebral haemorrhage is a rare complication of polyarteritis nodosa (PAN). We present the clinico-pathologic findings of a 62 year-old patient with systemic involvement by PAN, who developed temporary decrease of consciousness and a mild left hemisyndrome due to a small right dorsal thalamic haemorrhage. No clear cause for the haemorrhage was found on postmortem examination.

J.L. García1, I. Matos1, R. Lozano Mejorada1, E. Fonseca1, R. Benito2, A. Santos-Briz3, A. Brownrigg-Gleeson4, J.M. Hernandez-Rivas5, J.J. Cruz Hernandez1 Oncología Médica, Hospital Clínico de Salamanca, Salamanca, SPAIN Hematología, CIC-IBSAL, Salamanca, SPAIN Pathology, Hospital Clínico de Salamanca, Salamanca, SPAIN Cirugía, Hospital Clínico de Salamanca, Salamanca, SPAIN Hematología, Hospit...

Neurological, CT and high-field (1.5T) magnetic resonance imaging (MRI) data were correlated in 6 patients previously clinically diagnosed as having suffered small vertebrobasilar infarct. MRI demonstrated infarcts in areas where CT was nearly always negative. MRI allowed very precise clinico-topographic correlations and appears to be the preferred imaging technique in vertebrobasilar infarcts.