Osmotic cell swelling activates an outwardly rectifying Cl current in endothelial cells that is mediated by volume-regulated anion channels (VRACs). In the past, we have shown that serum-induced proliferation of endothelial cells is arrested in the presence of compounds that potently block the endothelial VRACs. Here we report on the effects of four chemically distinct VRAC blockers [5-nitro-2-...

OBJECTIVES To investigate factors associated with the response to ovarian stimulation in patients with polycystic ovary syndrome. Methods: The records of patients with polycystic ovary syndrome and infertility who underwent ovulation induction with clomiphene citrate were reviwed between January 2011 and December 2014 in Etlik Zübeyde Hanim Women's Health Training and Research Hospital Ankara, ...

In the early 1960's methods of promoting conception were based on therapy with compounds similar to follicle stimulating hormone (F.S.H.) and luteinizing hormone (L.H.) All were very expensive, had to be given by injection, and could lead to multiple pregnancies as individual sensitivity to them varied greatly. Interest in clomiphene was instigated when a similar compound MER-25, was given to f...

We examined the effects of enclomiphene and zuclomiphene, alone and in combination with oestradiol, on basal and gonadotrophin-stimulated progesterone secretion by isolated subpopulations of both large (granulosa-lutein) and small (theca-lutein) ovine luteal cells. Isolated large and small luteal cells derived from intact, enucleated ovine corpora lutea were incubated for 48-120 h with or witho...

Secondary hypogonadism is not an infrequent abnormality in older patients presenting with the primary complaint of erectile dysfunction. Because of the role of testosterone in mediating sexual desire and erectile function in men, these patients are usually treated with exogenous testosterone, which, while elevating the circulating androgens, suppresses gonadotropins from the hypothalamic-pituit...

This 23-year-old primigravida had history of having taken Clomiphene for 2 consecutive cycles starting on day 5 of her menstrual cycle (50 mg for five days). After the 2nd cycle of clomiphene, she became pregnant. There was no history of taking any other drug for infertility or folate tablets periconceptionally. An ultrasound at 20 weeks showed neural tube defect. At 22 weeks of gestation, she ...

We performed unilateral oophorectomy (UO) in three patients with polycystic ovary syndrome (PCOS) and long-standing infertility. The indication for performing this procedure was a combination of ovarian pathology and the long-standing infertility. All three patients were resistant to clomiphene citrate and before UO all patients had been treated unsuccessfully with gonadotrophins and in-vitro f...

In this study, we have determined the ability of the partial estrogen antagonists, clomiphene, tamoxifen, and nafoxidine, and the pure estrogen antagonists, ICI 164,384 and ICI 182,780, to inhibit angiogenesis in the chick egg chorioallantoic membrane. All of the partial estrogen antag onists and the pure estrogen antagonist, ICI 182,780, showed significant angiostatic activity in a dose-relate...