Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains examined. The compounds showed moderate in vitro antimalarial two P. falciparum strains, 3D7 (CQ susceptible clone) Dd2 resistant clone). Three aminoquinolines were further examined for efficacy a mouse model using modified Thompson test. In this model, mice infected with berghei-infec...

Why would anyone clone a sheep or a cow, let alone a human being? None save the genetic determinists who believe an organism is nothing more than the sum total of its genetic makeup and that it is their right to exploit cloned human embryos for spare body parts. Dr. Mae-Wan Ho explains why ‘clone’ is a misnomer. The original Dolly experiment was misguided, and subsequent attempts at cloning man...

In the last decade, several researchers have investigated techniques to detect duplicated code in programs exceeding hundreds of thousands lines of code. All of these techniques have known merits and deficiencies, but as of today, little is known on where to fit these techniques into the software maintenance process. This paper compares three representative detection techniques (simple line mat...

Polynomial-clone reducibilities are generalizations of the truth-table reducibilities. A polynomial clone is a set of functions over a finite set X that is closed under composition and contains all the constant and projection functions. For a fixed polynomial clone C, a sequence B ∈ X is C-reducible to A ∈ X if there is an algorithm that computes B from A using only effectively selected functio...

Abstract Clone detection has received much attention in many fields such as malicious code detection, vulnerability hunting, and copyright infringement detection. However, cyber criminals may obfuscate to impede violation To date, few studies have investigated the robustness of clone detectors, especially in-fashion deep learning-based ones, against obfuscation. Meanwhile, most these only measu...

Over 80% of human cancers originate from the epithelium, which covers outer and inner surfaces organs blood vessels. In stratified bottom layers are occupied by stem stem-like cells that continually divide replenish upper layers. this work, we study spread premalignant mutant clones cancer initiation in epithelium using biased voter model on stacked two-dimensional lattices. Our main result is ...

Campylobacter jejuni clone SA is the major cause of sheep abortion and contributes significantly to foodborne illnesses in the United States. Clone SA is hypervirulent because of its distinct ability to produce systemic infection and its predominant role in clinical sheep abortion. Despite the importance of clone SA, little is known about its distribution and epidemiological features in cattle....

We resolved the relationships between 2 pandemic clones of Vibrio cholerae. Using 26 housekeeping genes, we showed that the US Gulf clone, the Australian clone, and 3 El Tor strains isolated before the seventh pandemic were related to the seventh pandemic clone. The sixth pandemic clone was well separated from them.

A novel, methicillin-resistant [corrected] Staphylococcus aureus clone (Uruguay clone) with a non-multidrug-resistant phenotype caused a large outbreak, including 7 deaths, in Montevideo, Uruguay. The clone was distinct from the highly virulent community clone represented by strain MW2, although both clones carried Panton-Valentine leukocidin gene and cna gene.