BACKGROUND AND AIMS It has been reported that clonidine when used as an additive in a dose of 90 μg in adults increases the duration of peripheral nerve blocks. Hence, this study was conducted to evaluate the effect of clonidine in brachial plexus blocks and to compare it with tramadol. MATERIAL AND METHODS Ninety patients posted for upper limb orthopedic surgery were divided randomly into th...

Our previous attempts to investigate the long-term hemodynamic interaction between ethanol and clonidine in telemetered spontaneously hypertensive rats (SHRs) were hampered by the lack of a sustained hypotensive response to continuous clonidine exposure. This limitation was circumvented when we adopted a limited-access clonidine (8:30 AM-4:30 PM) paradigm in a recent study. The latter paradigm ...

The ability of hypoosmotic solution, prostaglandin E1 (PGE1) and clonidine to influence intraocular pressure (IOP) by a central mechanism was studied using the technique of ventriculocisternal perfusion in conscious rabbits. IOP remained unchanged during the perfusion of 150 mOsm artificial cerebrospinal fluid. IOP rapidly increased by 15 mmHg during the perfusion of PGE1 at the dose of 1 or 3 ...

BACKGROUND AND OBJECTIVES Clonidine is added to intrathecal local anesthetics to improve intraoperative analgesia and to increase the duration of sensory and motor block. The aim of this systematic review is to quantify beneficial and harmful effects of clonidine when used as an adjuvant to intrathecal local anesthetics for surgery. METHODS We included data from 22 randomized trials (1,445 pa...

BACKGROUND AND OBJECTIVES Clonidine and dexmedetomidine are alpha2-adrenergic agonists with analgesic proprieties which potentiate local anesthetic effects when epidurally administered. The goal of this study was to evaluate the analgesia and sedation promoted by clonidine or dexmedetomidine associated to epidural ropivacaine, in the postoperative period of subcostal cholecystectomy. METHODS ...

BACKGROUND Through their action on the locus coeruleus, alpha2-adrenoceptor agonists induce rapidly reversible sedation while partially preserving cognitive brain functions. Our goal in this observational study was to map brain regions whose activity is modified by clonidine infusion so as to better understand its loci of action, especially in relation to sedation. METHODS Six ASA I-II right-...

UNLABELLED This work provides results of therapeutic efficacy testing and clonidine toleration in moderating of perioperative tachicardia and hypertension, as well as reducing the needs for anaestathic drugs, thus providing better patients' cardiovascular stability. MATERIAL AND METHODS The study involved 60 patients, that were subdued to elective non-cardiosurgical operations in general anae...

Clonidine is a centrally acting, -2 adrenergic agonist used for the treatment of hypertension during pregnancy. The metabolic pathways of clonidine are poorly understood, and the quantitative contribution of specific human cytochrome P450 (P450) isoforms has not been systematically assessed. In this study, 17 cDNA-expressed P450 enzymes, in addition to pooled human liver microsomes, were evalua...

OBJECTIVE Clonidine, which inhibits locus coeruleus discharge, would seem for theoretical reasons to be a good antipanic drug. Panic disorder (PD) presents a heterogeneous cluster of symptoms and a classification based on subtypes has been suggested and the respiratory symptoms group appears as a distinct subtype. METHOD We report three cases of respiratory PD patients who were successfully t...

Most clinicians believe that clonidine has minimal abuse potential. Originally introduced as an antihypertensive agent in 1974, clonidine is inexpensive and has well-known and tolerable side effects. In recent years it has been used in a wide variety of clinical situations, including the treatment of opiate dependence and numerous psychiatric disorders in both adults and children. 1 Despite its...