were heard over the lower third of the right lung, without reduced air entry or dullness on percussion. Pitting edema of both lower extremities was present. Otherwise, the physical examination was unrevealing. Her blood tests showed mild anemia (hemoglobin 11 g/L, mean cell volume 78 fl), normal number of white blood cells and platelets, normal level of serum electrolytes, urea and creatinine; ...

The structure of the yeast Sfi1-centrin complex, and its asymmetric position within the yeast centrosome, suggest a model for the initiation of centrosome duplication and provides a target for licensing this event.

E1152 CMAJ, October 18, 2011, 183(15) © 2011 Canadian Medical Association or its licensors A33-year-old man from a rural Taiwanese village was admitted with a three-day history of fever, headache, muscle pain and skin rashes. On examination, he was febrile (39.2°C) with generalized macular patches and an eschar measuring 15 mm on the left lower quadrant of his abdomen (Figure 1). His leukocyte ...

Microangiopathic hemolytic anemia (MAHA), is one of the causes of extra vascular hemolysis. It is seen in settings with pathologically altered small blood vessels. Disseminated carcinomas may rarely present as MAHA. A case of a 28 year old female with carcinoma stomach, who presented with MAHA as a first manifestation is reported. Acute onset of MAHA, may be the first manifestation of malignanc...

Dear Editor, Pseudo hypertension (HTN) is a condition in which indirect blood pressure (BP) measured by the cuff method overestimates the true intra‐arterial BP.[1] It should be suspected if a patient develops dizziness after the start of antihypertensive or following dose escalation. The direct measurement of intra‐arterial BP is the gold standard for its diagnosis. However, it is an invasive ...

Recent advancement of large-scale pretrained models such as BERT, GPT-3, CLIP, and Gopher, has shown astonishing achievements across various task domains. Unlike vision recognition language models, studies on general-purpose user representation at scale still remain underexplored. Here we explore the possibility learning by training a universal encoder large scales. We demonstrate that scaling ...

Angiosarcomas of the scalp are aggressive invasive tumors that, more often than not, mimic benign painless skin lesions. We here report a case of angiosarcoma that was timely diagnosed and treated thanks to the dermoscopic rainbow pattern.

The list of references is available in the online version of this paper. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

Mahadevan S, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220259 DESCRIPTION A 72-year-old man presented for general health check. He was asymptomatic except for hard of hearing and uses hearing aid for the last 4 years. Clinical examination revealed very prominent tortuous superficial temporal veins bilaterally, more on the left side (figure 1) with no bruit and a warm non-tender skull on pa...

Topical administration is the most common route of ocular drug delivery. Despite its apparent easy accessibility, the eye is well protected from foreign materials and drugs by a number of very efficient mechanisms such as blinking, induced lacrimation, tear turnover, nasolacrimal drainage, which cause rapid removal of substances from the eye surface and by the cornea, which forms the physical-b...