A Central nervous system (CNS) hemorrhage is bleeding in or around the brain and spinal cord. Reasons of CNS hemorrhage include high blood pressure, cancers, drug abuse, abnormally weak blood vessels that leakage, and trauma. Regression of CNS bleeding was confirmed to be relatively repetitive in patients with severe FV, FX, FVII and FXIII deficiencies. Generally in CNS hemorrhage, radiological...

how to cite this article: khoddami m, akbarzadeh a, mordai a, bidari zerehpoush f, alipour h, samadzadeh s, alipour b.diagnostic accuracy of frozen section of central nervous system lesions: a 10-year study. iran j child neurol. 2015 winter;9(1):25-30.   abstract objective definitive diagnosis of the central nervous system (cns) lesions is unknown prior to histopathological examination. to dete...

objective: premna integrifolia linn (family: verbenaceae) synonym of premna serratifolia has tremendous medicinal value. preliminary pharmacological studies were performed on the methanolic extract of premna integrifolia (mepi) bark to investigate neuropharmacological, analgesic, and anti-inflammatory activities. materials and methods: neuropharmacology study was done by open field and hole cro...

Primitive neuroectodermal tumors (PNET) of the brain include medulloblastoma (MB) and central nervous system primitive neuroectodermal tumor (CNS PNET) subtypes, which share histological features yet differ at the genomic level and in clinical outcome. Delineation of the genetic anomalies between PNET subtypes is a current challenge for establishing effective targeted therapeutic strategies aga...

0

Abstract BACKGROUND Our previous studies has developed an adoptive cellular therapy (ACT) against high grade gliomas in both human and murine systems. ACT significantly improves survival models of CNS malignancies. have shown that efficacy is associated with the observed increase tumor-associated dendritic cells (DC) which arise from transferred hematopoietic stem (HSC). HSC-derived DCs play a ...

Objectives: The characteristics of 144 Iraqi children with primary CNS tumors were reviewed to identify median age at presentation, the disease distribution in terms gender, main presenting symptoms, most common grade and histological subtypes, predominant subsites which central nervous system malignancies arise from, according WHO 2016 classification. Patients methods: Medical records used col...

Abstract Background Hematopoietic stem cell transplant (HSCT) has been increasingly used in the last few decades, with improved success offering a cure. CNS complications are an important contributor to morbidity and mortality HSCT patients. The aim of study was evaluate role imaging detection assessment CNSC (central nervous system complications) after pediatric oncology included consecutive p...

Abstract BACKGROUND: Limited data exist regarding checkpoint inhibitor efficacy for pediatric CNS malignancies. METHODS: CheckMate 908 is an open-label, sequential-arm, phase 1b/2 study investigating nivolumab (NIVO) and NIVO + ipilimumab (IPI) in 5 cohorts of patients previously treated with standard-of-care (NCT03130959). Patients received NIVO-3mg/kg Q2W or IPI-1mg/kg Q3W (4 doses) followed ...

introduction acute disseminated encephalomyelitis (adem) is an acute inflammatory and demyelinating disease of the central nervous system, resulting in various neurological symptoms. usually, the disease appears following vaccination or systemic viral infections. in rare cases, the disease appears following pneumococcal infections. case presentation the patient was a 27 year-old man who was ref...