Central nervous system (CNS) metastases from breast cancer are common and can present as the first or solitary site of disease progression. The CNS has been reported to act as a sanctuary site that denies access to many chemotherapeutic agents. We present here, a series of 10 metastatic breast cancer patients who developed CNS metastases after an initial response to trastuzumab treatment. Forty...

Methamphetamine (MA) is a potent, addictive psychostimulant that has dramatic effects on the central nervous system (CNS). The onset of methamphetamine use has been linked to heightened attention, and chronic methamphetamine use has been associated with deficits in different aspects of attention that can significantly persist into abstinence. Attention deficits in chronic methamphetamine users ...

Primaquine phosphate has been used for preventing relapse of Plasmodium vivax and P. ovale malaria since the early 1950s, based on its ability to kill latent (hypnozoite) and developing liver stages of these parasites. There are three uses for primaquine in malaria: radical cure of established infection with P. vivax or P. ovale malaria; presumptive anti-relapse therapy (PART; terminal prophyla...

inal symptoms at the same intensity as before treatment, entailing a return of the same episode and a new episode of illness, respectively [6, 9] . When treatment with a CNS drug is discontinued, patients can experience classic new withdrawal symptoms, rebound and/or persistent postwithdrawal disorders, or relapse/recurrence of the original illness [6, 9, 14] . New and rebound symptoms can occu...

the blood brain-barrier, trimethoprim/sulphamethoxazole (160/800 mg every 8 hours) and amikacin (500 mg every 12 hours). The patient’s clinical condition slowly deteriorated and the patient died 73 days after the start of the antibiotic treatment. Post-mortem examination confirmed the diagnosis of CNS and pulmonary nocardiosis. Infection remains a major cause of significant morbidity and mortal...

A 35-year old man presented with acute myeloid leukemia (AML-M2), with 45, X, -Y, t(8;21)(q22;q22) [8] and AML1-ETO fusion. A molecular remission was obtained by 7+3 induction followed by high dose Ara-C and 5+2 consolidations x4. One year later, he presented with left eye proptosis and double vision. Magnetic resonance imaging studies confirmed left lacrimal gland swelling (Figure 1A and B) wi...

To identify the subgroups of patients with malignant non-Hodgkin's lymphomas who might benefit from prophylactic therapy to prevent CNS relapse, lumbar puncture was routinely performed among the other staging procedures from January 1976 to October 1979 in 76 patients with diffuse lymphomas. The study also takes into consideration 32 patients who came to out observation during the same period a...

Two hundred and one patients (median age, 29 years) with acute myeloid leukemia (AML) underwent bone marrow transplantation (BMT) from HLA-identical sibling donors after conditioning with melphalan-total-body irradiation (TBI) (57%), cyclophosphamide-TBI (35%), or chemotherapy alone (8%). Graft-versus-host disease (GVHD) prophylaxis included cyclosporine alone (68%), cyclosporine-methotrexate (...

Currently, the treatment for central nervous system (CNS) and neurocognitive fluctuations as a result of sports injuries is considered relatively uncovered area under neuroscience paradigm. For example, compensatory neural changes (e.g., brain cortical changes) cognitive load can create feedforward loop that affects recovery relapse after musculoskeletal injury. Although several methodologies h...