BACKGROUND Recently released studies indicate that activation of blood coagulation may be involved in causing urticaria. OBJECTIVE To evaluate whether or not anticoagulation, fibrinolysis and the complement system are also involved in the pathogenesis of urticaria. METHODS Coagulant factors, anticoagulant factors, fibrinolytic markers and complement components were analysed in patients with...

  Objective(s): Echis carinatus is one of the venomous snakes in Iran. The venom of Iranian Echis carinatus is a rich source of protein with various factors affecting the plasma protein and blood coagulation factor. Some of these proteins exhibit types of enzymatic activities. However, other items are proteins with no enzymatic activity.   Materials and Methods: In order to study the mechanism ...

By YALE NEMERSON AND THEODORE H. SPAET W HEN BLOOD is allowed to clot in vitro without the addition of other reagents, a complex sequence of events occurs which involves the participation of numerous coagulation factors, all of which are derived from the blood itself. This process is now generally known as “intrinsic coagulation.” Extracts of tissues markedly accelerate coagulation by bypassing...

Blood coagulation in vivo is a spatially nonuniform, multistage process: coagulation factors from plasma bind to tissue factor (TF)-expressing cells, become activated, dissociate, and diffuse into plasma to form enzymatic complexes on the membranes of activated platelets. We studied spatial regulation of coagulation using two approaches: 1), an in vitro experimental model of clot formation in a...

Endothelial dysfunction, one of many causes arterial changes in end-stage kidney disease (kidney failure), is a likely link between early vascular aging and the risk thrombosis or bleeding this condition. To evaluate this, we compared links stiffness endothelial/coagulation factors 55 patients receiving hemodialysis therapy 57 age-/sex-matched control individuals. Arterial was assessed from car...

KB We usually use prestorage leukoreduced red blood cells to treat symptomatic anemia, and leukoreduced apheresis platelets or whole blood–derived platelets to treat thrombocytopenia. Plasma components are used less commonly, and their use generally is restricted to the treatment of bleeding associated with coagulation factor deficiencies—either isolated coagulation factors or multiple coagulat...

Snake venom serine proteinases affect many steps of the blood coagulation cascade. Each of them usually acts selectively on one coagulation factor. They are therefore potentially useful components to study the mechanisms of action, the regulation and the structure-function relationships of human serine proteinase coagulation factors. This strategy is illustrated for a plasminogen activator puri...

Background: Hemophilia B is an X-linked hereditary disorder of blood coagulation system which is caused by factor IX (FIX) deficiency. Factor IX is a plasma glycoprotein that participates in the coagulation process leading to the generation of fibrin. Replacement of factor IX with plasma-derived or recombinant factor IX is the conventional treatment for hemophilia B to raise the factor IX le...