severe overgrowth and tallness is very rare in human beings. the most common cause is gigantism due to the excessive secretion of the growth hormone, especially, before the closure of long bones’ epiphyseal growth plates. there are other rare disorders that are categorized on overgrowth syndromes. herein, we report an extremely rare, or even perhaps a unique, patient from iran. the clinical and...

macrophage activating syndrome (mas) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, still's disease, polyarteritis nodosa. it is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. a 27 yr. old female patient was admitted in shahid mostafa khomeini hospital (tehra...

primary immunodeficiencies (pid) are a group of disorders, characterized by an unusual susceptibility to infections. delay in diagnosis results in increased morbidity and mortality in affected patients. the purpose of this study was to determine the mortality rate of iranian immunodeficient patients referred to children medical center hospital affiliated to tehran university of medical sciences...

Susac’s syndrome consists of the clinical triad of encephalopathy, branch retinal artery occlusions, and hearing loss. In 1975, I saw two patients with this syndrome within a matter of 3 weeks while serving in the United States Army at Walter Reed Army Hospital. The first patient was presented to me at a conference in Albany, New York, and the second was referred to me by Dr. John Selhorst. I r...

137 interleukin-5-producing T cells in idiopathic eosinophilia. New Engl J Med 1999;341:1112-20. 7. Roufosse F, Schandene L, Cogan E. Idiopathic eosinophilia. N Engl J Med 1999;342:660. 8. Bassan R, Locatelli G, Borleri G, Salvi A, Barbui T. Immunophenotypic evaluation of circulating T-cell clones in hypereosinophilic syndromes with or without abnormal CD3 and CD4 lymphocytes. Haematologica 200...

goner AD, Miller RR, Quinones MA: Incidence and natural history of mural thrombi in acute myocardial infarction by two-dimensional echocardiography. Circulation 64:fV-93, 1981. 12. Keating EC, Gross SA, Schlamowitz RA, Glassman J, Mazur JH, Pitt WA, Miller D: Mural thrombi in myocardial infarctions. Prospective evaluation by two-dimensional echocardiography. Am J Med 74:989, 1983. 13. Friedman,...

superior vena cava (svc) syndrome is not an uncommon occurrence in patients with malignancy and it is often described as a medical emergency. in majority of the cases, svc syndrome occurs due to mechanical obstruction of the svc by extraluminal compression with primary intrathoracic malignancies. however, intraluminal obstruction due to thrombosis can also produce symptoms and signs of svc synd...

in this case report, we present the first diagnosed case of galloway- mowat syndrome in iran. a 7 month old infant boy with microcephaly that had prominently stunted head growth after birth, gastroesophageal reflux, multiple craniofascial characters, hypothyroidism and nephrotic syndrome diagnosed at 5 months of age associated with rapid decline in renal function and heavy proteinuria in 2 mont...