نتایج جستجو برای: cognitive aging
تعداد نتایج: 343878 فیلتر نتایج به سال:
It has long been proposed that cognitive aging in fluid abilities is driven by age-related declines of processing speed. Although study of between-person associations generally supports this view, accumulating longitudinal between-person and within-person evidence indicates less strong associations between speed and fluid cognitive performance. Initial evidence also suggests that cognitive flex...
Environmental enrichment has become increasingly utilized in rodent models of aging and neurodegenerative disease in order to prevent or reverse cognitive decline and neuronal dysfunction. However, the potential application of this body of work to human cognitive aging has rarely been discussed. The present article provides an overview of the rodent research that has tested the effects of envir...
Successful aging without cognitive decline (SA) is apparent in those who escape age-related illnesses, such as cardiovascular disease and dementia. To determine whether there are protective genotypes that increase the probability of successful cognitive aging, a genome-wide screen was conducted on subjects who were 85 years of older, had MMSE scores >26, and had no major illnesses. SNP 500K mic...
A leaky blood-brain barrier has long been implicated in cognitive dysfunction in aging and neurodegeneration, but reliable human data were lacking. Here, Montagne et al. (2015) provide the first in vivo evidence of blood-brain barrier disruption in the aging hippocampus and in minimal cognitive impairment.
In order to address pathological cognitive decline effectively, it is critical to adopt early preventive measures in individuals considered at risk. It is therefore essential to develop approaches that identify such individuals before the onset of irreversible dementia. A deficient cholinergic system has been consistently implicated as one of the main factors associated with a heightened vulner...
Cognitive decline is commonly observed in advanced aging even in the absence of disease. Here we explore the possibility that normal aging is accompanied by disruptive alterations in the coordination of large-scale brain systems that support high-level cognition. In 93 adults aged 18 to 93, we demonstrate that aging is characterized by marked reductions in normally present functional correlatio...
Aging is the primary risk factor for cognitive decline, an emerging health threat to aging societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. We show that a lifespan-extending variant of the human KLOTHO gene, KL-VS, is associated with enhanced cognition in heterozygous carriers. Because this allele increased klotho levels in serum, we an...
Aging is not a uniform process. In the general population, there is a paradox of aging: age-associated decline in physical and some cognitive functions stands in contrast to an enhancement of subjective quality of life and psychosocial functioning. This paradox is even more striking in people with schizophrenia. Compared with the overall population, individuals with schizophrenia have accelerat...
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