statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. this study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). all animals were dec...

background: prepubertal varicocele has the most devastating effects on the testes. oxidative stress is the major cause leading to infertility in varicocele. the antioxidant properties of flaxseed (fs) treatment in some oxidative diseases have been reported. objective: this study aimed to evaluate the antioxidant effect of fs in prepubertal rats with experimental varicocele. materials and method...

based on the evidence regarding the relationship between inflammatory processes and stress responses, the present study investigated the association between psychological stress and elevation of inflammatory mediators related to periodontal disease in adult patients.the study consisted of 50 patients including 25 patients with chronic periodontitis and 25 cases with aggressive periodontitis. tw...

background: there are some challenges about the role of work- related stress on development of musculoskeletal complaints. the present prospective study was conducted on nurses of milad hospital in tehran (iran) to assess the role of work- related stress on development of neck and shoulder pain among nurses.   methods: from the 1,900 nurses who completed the registry forms, 1,450 nurses met the...

conclusion tf-cbt for patients with acute stress disorder has been shown to be efficacious in reducing the likelihood of subsequent development of ptsd. despite the impressive level of empirical support for tf-cbt, many professionals remain unaware of its advantages and many children and parents who could benefit do not receive such treatment. further more, in iran, there may not yet be any tf-...

introduction: acrylamide (acr) known as a neurotoxic agent in human and animals. previous studies have been shown; fasudil improves neurological deficit and neuronal damage. in this study, the effect of fasudil, potent rho-kinase inhibitor, on acr-induced cytotoxicity was evaluated using pc12 cells as a suitable in vitro model. materials and methods: pc12 cells were exposed to different concent...

introduction: today, stress is one of the human’s problems particularly in developing and developed countries. so, many people try to determine these factors and presented suitable solutions. the purpose of this research was to determine job stressors among librarians of isfahan university of medical sciences, iran in 2009. methods: this study was survey research in which data was collected by ...

conclusions hemodialysis exacerbates oxidative stress and conformational changes of hb in patients with diabetes on hemodialysis. the frap value can be used as a positive determinant, while pco and hb derivatives can be used as negative determinants of oxidative stress in patients with diabetes. background diabetes is associated with an increased generation of reactive oxygen species (ros), whi...

objective: hexavalent chromium [cr (vi)] compounds are well-known environmental contaminants  generated from industrial processes. several studies have reported the harmful effects of cr (vi) on different organs, however, little is known about neurotoxic effects of cr (vi). the aim of this study is to investigate the toxic effects of cr (vi) on pc12 cells. methods: pc12 cells were cultured foll...