We describe an encoding of major parts of domain theory and xed-point theory in the Pvs extension of the simply-typed-calculus; these formaliza-tions comprise the encoding of mathematical structures like complete partial orders (domains), domain constructions, the Knaster-Tarski xed-point theorem for mono-tonic functions, and variations of xed-point induction. Altogether, these encodings form a...

Fixed point calculus is about the solution of recursive equations de ̨ned by a monotonic endofunction on a partially ordered set. This tutorial presents the basic theory of ̨xed point calculus together with a number of applications of direct relevance to the construction of computer programs. The tutorial also presents the theory and application of Galois connections between partially ordered se...

One grazing and two feeding experiments were conducted to compare the feeding value of corn residue or corn grain from a genetically enhanced corn hybrid (corn rootworm-protected; event MON 863) with nontransgenic, commercially available, reference hybrids. In Exp. 1, two 13.7-ha fields, containing corn residues from either a genetically enhanced corn root-worm-protected hybrid (MON 863), or a ...

This paper presents the management overlay network (MON) system that we are building and running on the PlanetLab testbed. MON is a distributed system designed to facilitate the management of large distributed applications. Toward this goal, MON builds on-demand overlay structures that allow users to execute instant management commands, such as query the current status of the application, or pu...

Germline mutations of the hit SI 12 gene are responsible for many cases of hereditary nonpolyposis colorectal cancer. While screening for HMSH2 gene mutations in hereditary nonpolyposis colorectal cancer kindreds, we observed that a previously reported germline mutation is in fact a com mon, alternatively spliced variant in the population. Using RT-PCR and the protein truncation test, the hMSH2...

Sev eral char ac ter is tics of the ba sic types of ox i da tive DNA dam age are ana lysed in the pres ent work. They are as fol lows: base and sugar mod i fi ca tions le sions, sin gle-strand and dou ble-strand breaks, apurinic/apyrimidinic sites and DNA-pro teins cross-links. The chem i cal struc ture of the most in ves ti gated types of ox i da tive DNA dam age is shown. The most com mon gen...

Acute leukemia comprises of 31% of all cancers in children making it the most com‐ mon childhood malignancy. Significant strides have been made in treatment, partly through risk stratification and intensified therapy. A number of subtypes remain at high risk for relapse and poor outcome, despite current therapies. Here we describe risk stratification and molecular diagnosis used to identify hig...

The problem of forming validation regions or gates for new sensor mea surements obtained when tracking targets in clutter is considered Target dynamics and measurement characteristics are modeled with possible non Gaussianities or nonlinearities so that some degree of approximation is usually required in the computation of the ltering densities for the target position and predictive densities f...

Several m ajor classes o f herbicides, discovered by conventional screening techniques, have been found to inhibit the first com m on enzyme o f branched-chain am ino acid biosynthesis, acetolactate synthase, as their m ode o f action. These herbicides seem to bind to an evolution­ ary vestige o f a quinone-binding site, extraneous to the active site, that is present due to the evolutionary his...