INTRODUCTION Hydatidiform moles (HM), presenting as complete (CHM) and partial (PHM) form, are rare pregnancy disorder. Diagnosis is based on clinical presentation, ultrasound imaging findings and pathological examination of products of conception. Protein p57, encoded by CKDN1C gene, is paternally imprinted and maternally expressed gene and provides quick insight in genetic basis of HM and all...

BACKGROUND Ectopic molar gestation is a rare event. Its malignant potential is similar to that of an intrauterine molar pregnancy. OBJECTIVE To document two cases of tubal molar gestations seen over a 10-year period. STUDY DESIGN Case series. RESULTS Two young Nigerian undergraduates presented with features of ruptured tubal pregnancy. They had total salpingectomy and histopathological an...

AIMS To determine whether the expression of proliferating cell nuclear antigen (PCNA) in villous cytotrophoblast could distinguish between placental tissue from a hydropic abortion and that from a partial hydatidiform mole. METHODS Tissue from 18 partial hydatidiform moles, 15 hydropic abortions, five normal first trimester placentas and five normal full term placentas were immunostained for ...

AIMS To compare the expression of c-myc and c-fms proto-oncogenes in the placenta and hydatidiform mole. METHODS Twelve hydatidiform moles and six induced abortion cases were collected. c-myc and c-fms proto-oncogene expression was analysed by northern blot hybridisation and immunohistochemical staining. RESULTS The results of northern blot hybridisation analysis showed that c-fms was expre...

The aim of this study was to evaluate the usefulness of maternal serum markers in the early prenatal diagnosis of molar pregnancies. The ultrasound features, cytogenetic and histopathological findings of 10 cases of molar pregnancy diagnosed at 11-13 weeks of gestation were compared retrospectively with the maternal serum concentrations of human chorionic gonadotrophin (HCG), alpha fetoprotein ...

BACKGROUND & OBJECTIVES There is considerable inter-observer variability in the diagnosis of molar pregnancies by histomorphological examination of products of conception (POC). The p57KIP2 gene is paternally imprinted and expressed from the maternal allele. On immunohistochemistry (IHC) with p57, complete mole (CM) shows absent staining whereas hydropic abortus (HA) and partial mole (PM) show ...

OBJECTIVES To determine epidemiological characteristics and clinical presentation of complete hydatidiform mole (CHM) and complications associated with prophylactic chemotherapy with oral methotrexate. SETTING Mulago hospital, Kampala. DESIGN Prospective study. METHODS Ninety-four patients with clinically and histologically confirmed complete hydatidiform mole admitted between 1/9/1995 an...

A 31-year-old lady presented with abnormal vaginal bleeding during her first trimester of pregnancy. Based on the ultrasound findings and decreasing hCG trend (from 1040 mIU/mL to 759 mIU/mL), a diagnosis missed miscarriage was made. week later, patient heavy bleeding. Ultrasound showed classic snowstorm appearance suggestive complete hydatidiform mole. The serum level however, 357 mIU/mL. In c...

Twin pregnancy consisting of complete molar pregnancy and a coexisting fetus occurs with an estimated incidence of 1 per 22,000–100,000 pregnancies, and may be increasing due to the greater use of assisted reproductive techniques [1]. These pregnancies are associated with significant maternal and fetal complications including preeclampsia, thromboembolic disease, hyperemesis, hemorrhage, intrau...