PURPOSE The aged Royal College of Surgeons (RCS) rat with advanced retinal degeneration loses the b-wave and shows a negative-going corneal electroretinogram (ERG) that has been attributed to loss of inner retinal function because of glutamate toxicity. The authors investigated the origin of this negative ERG and evaluated inner retinal function in late-stage RCS degeneration. METHODS The ERG...

In this paper, a closed-loop location-inventory problem for spare parts is presented. The proposed supply chain network includes two echelons, namely (1) distribution centers (DCs) and repairing centers (RCs) and (2) operational bases. Multiple spare parts are distributed among operational bases from distribution centers in the forward supply chain and failed spare parts from operational bases ...

abstract according to the adventages of passive radars they have been reconsidered recently due to development of signal processing technology. in the field of sea targets detection using passive radar few research have been reported. this paper presents a new method to detect sea targets using adaptive filter weights variation model and using the fact that the radar cross section of sea target...

A membranous fraction that could synthesize viral RNA in vitro in the presence of magnesium salt, ribonucleotides, and an ATP-regenerating system was isolated from feline calicivirus (FCV)-infected cells. The enzymatically active component of this fraction was designated FCV replication complexes (RCs), by analogy to other positive-strand RNA viruses. The newly synthesized RNA was characterized...

PURPOSE Subretinal prosthetics are designed to electrically stimulate second-order cells, replacing dysfunctional photoreceptors in diseases such as retinitis pigmentosa (RP). For functional vision to occur, this signal must also reach central visual structures. In the current study, a subretinally implanted prosthetic was evaluated in the Royal College of Surgeons (RCS) rat model of RP, to det...

The proposed light-frame structure comprises steel columns for vertical loads and an innovative bracing system to efficiently resist seismic actions. This seismic force resisting system consists of a light timber frame braced with an Oriented Strand Board (OSB) sheet and an external technoprene plaster-infilled slab. Steel brackets are used as foundation and floor connections. Experimental cycl...

Peritoneal macrophages from RCS rats exhibit phagocytic capability equal to that found in macrophages from normal strains of rat. The similarity in phagocytic activity was found with rat or bovine rod outer segments as well as with dystrophic retinal debris. Thus the genetic defect in RCS pigment epithelium is not expressed in the macrophages, which are available to clear the debris layer that ...

PURPOSE To determine whether treatment with bright light elicits a protective response that enhances photoreceptor survival in Royal College of Surgeons (RCS) rats with inherited retinal degeneration. METHODS RCS rats were illuminated for 10 to 12 hours with 130 foot-candles (fc) of white or green light. Untreated littermates that were kept under low cyclic light levels were used as control s...

BACKGROUND Assessing primary rehabilitation needs in patients with acquired brain injury is a challenge due to case complexity and the heterogeneity of symptoms after brain injury. The Rehabilitation Complexity Scale-Extended (RCS-E) is an instrument used in assessment of rehabilitation complexity in patients with severe brain injury. The aim of the present study was to translate and test the f...