Excessive mechanical loads on the temporomandibular joint (TMJ) can cause mandibular cartilage degradation and subchondral bone erosion, but the treatment of these conditions remains challenging. Salubrinal, which target eukaryotic translation initiation factor 2 alpha, has been shown to have multiple beneficial effects on skeletal tissue. Here, we examined the effect of a Salubrinal injection ...

A1. The temporary skeletal anchorage device used in this study, C-implant, requires higher removal torque compared to other orthodontic mini-implants because of its greater osseointegration potential. It also means that the C-implant allows application of multi-directional force system such as retraction combined with intrusion by concurrent use of intraand intermaxillary elastics. In such case...

The general principles behind the global mechanical tensioning technique for controlling weld residual stresses are examined using a finite lement model to follow their evolution throughout the welding process. While we focus specifically on friction stir welding, the tool is represented imply as a heat source. As a result, the findings have relevance to a wide range of welding processes. For a...

In Japan, the most common articular disease is knee osteoarthritis. Among many treatment methodologies, tissue engineering and regenerative medicine have recently received a lot of attention. In this field, cells and scaffolds are important, both ex vivo and in vivo. From the viewpoint of effective treatment, in addition to histological features, the compatibility of mechanical properties is al...

When an impurity is doped in a solid, it inevitably induces a local stress, tending to expand or contract the lattice. Consequently, strain can be applied to change the solubility of impurity in a solid. Generally, the solubility responds to strain "monotonically," increasing (decreasing) with the tensile (compressive) strain if the impurity induces a compressive stress or vice versa. Using fir...

Large meteorite impacts cause great changes to geologic features on Earth, ranging from cratering and ejecta blankets to phase transformations in minerals. In this report we describe the effect of a shock wave on the crystallographic orientation of quartz crystals in quartzite from the Vredefort impact site in South Africa. Preferred orientation of bulk quartzite samples was measured by time-of...

Morphology, structure, residual stress, and surface energy of magnetron-sputtered titanium nitride (TiN) thin films, deposited at 300 C with a thickness in the 0.5-1.7 lm range, were characterized. Film microstructure, the origin of residual stress, and its effect on the surface energy were analyzed. The grain size increased with the film thickness. X-ray diffraction showed (200) to (111) prefe...

We have studied numerically the stability and defect nucleation in epitaxial layers on a substrate with lattice mismatch. Stress relaxation and energy barriers for mis t dislocation nucleation are estimated using modern methods for saddle point search based on a combination of activation with local repulsive potential and the Nudged Elastic Band method. Stress relaxation processes correspond to...

To improve the efficacy of extracorporeal shock wave lithotripsy (ESWL) treatment, it is desirable to identify the physical properties of urinary calculi could offer direct correlation with their fragilities during ESWL and thus could be used to guide treatment procedures for more effective stone fragmentation. Thirty stone specimens removed surgically were compressed by an axial testing system...

Compressive stress may be involved in temporomandibular joint (TMJ) synovitis, but its mechanism has not been fully elucidated. We hypothesized that mechanical stress to the synovial cells of the TMJ potentially causes degenerative changes in temporomandibular joint disease. We examined the effect of cyclic compressive loading on three-dimensionally engineered constructs using human TMJ synoviu...