We describe a decision support system for hypothesis assessment in which exploration is supported by computational creativity. A software tool for morphological hypothesis analysis and evidence handling is extended with a creative assistant that on demand suggests hypotheses that the analyst should consider. Suggested hypotheses are chosen so that they are far from hypotheses that the analyst p...

This paper presents a computational analysis of Gondi dialects spoken in central India. We present a digitized data set of the dialect area, and analyze the data using different techniques from dialectometry, deep learning, and computational biology. We show that the methods largely agree with each other and with the earlier non-computational analyses of the language group.

An approach to modeling cognitive development with a generative connectionist algorithm is described and illustrated with a new model of conservation acquisition. Among the conservation phenomena captured with this model are acquisition, the problem size effect, the length bias effect, and the screening effect. The simulations suggest novel explanations for sudden jumps in conservation performa...

Microarray experiments are providing unprecedented quantities of genome-wide data on gene-expression patterns. Although this technique has been enthusiastically developed and applied in many biological contexts, the management and analysis of the millions of data points that result from these experiments has received less attention. Sophisticated computational tools are available, but the metho...

Mutation frequencies vary along a nucleotide sequence, and nucleotide positions with an exceptionally high mutation frequency are called hotspots. Mutation hotspots in DNA often reflect intrinsic properties of the mutation process, such as the specificity with which mutagens interact with nucleic acids and the sequence-specificity of DNA repair/replication enzymes. They might also reflect struc...

The human body requires a complex circulatory system to supply nutrients to, and to remove metabolic waste products from, its tissues. Given this primary purpose, circulatory function is closely related to the hemodynamic characteristics of blood vessels. This includes not only macroscale fluid dynamics, but also mass transfer in the microvasculature. Many experimental and clinical studies have...

Noncoding RNAs have emerged as important key players in the cell. Understanding their surprisingly diverse range of functions is challenging for experimental and computational biology. Here, we review computational methods to analyze noncoding RNAs. The topics covered include basic and advanced techniques to predict RNA structures, annotation of noncoding RNAs in genomic data, mining RNA-seq da...

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