1. The role of enhanced aerobic glycolysis in the transformation of rat thymocytes by concanavalin A has been investigated. Concanavalin A addition doubled [U-(14)C]glucose uptake by rat thymocytes over 3h and caused an equivalent increased incorporation into protein, lipids and RNA. A disproportionately large percentage of the extra glucose taken up was converted into lactate, but concanavalin...

Superoxide anion release from polymorphonuclear leukocytes stimulated by concanavalin A was markedly enhanced by the simultaneous addition of cytochalasin A at concentrations of 2x10-s to 4x10-1M. These concentrations of cytochalasin A did not affect the phagocytosis of diisodecyl phthalate emulsion. These concentrations were far lower than those of cytochalasins B, C, D and E that also enhance...

The binding of 8-anilinonaphthalene sulfonate to concanavalin A has been investigated. Isothermal titration calorimetry (ITC) and circular dichroism studies have been performed under different experimental conditions to understand the binding quantitatively and evaluate contributions of different forces responsible for it. Isothermal titration calorimetric results of concanavalin A with ANS at ...