A series of novel J147 derivatives were synthesized, and their inhibitory activities against β-amyloid (Aβ) aggregation and toxicity were evaluated by using the oligomer-specific antibody assay, the thioflavin-T fluorescence assay, and a cell viability assay in the transformed SH-SY5Y cell culture. Among the synthesized J147 derivatives, 3j with a 2,2-dicyanovinyl substituent showed the most po...

introduction: advanced oxidation processes (aops) suggest a highly reactive, nonspecific oxidant namely hydroxyl radical (oh•), that oxidize a wide range of pollutants fast and non-selective in wastewater and water. materials and methods: in this work, the nitrogen-doped titanium dioxide nanoparticles were primed by sol-gel method, characterized by x-ray diffraction and scanning electron micros...

The diurnal fluctuation of nitrate concentration in the foliage of three parsley subspecies (plain-leafed, curly-leafed and turnip rooted parsley) cultivated in the spring and autumn of two consecutive years was examined. Nitrogen was applied at 30 (Control), 75, 150, 300 mg kg-1 in both years, but with the addition of 450 mg kg-1 in year 2. Harvest was carried out at 08:30, 12:30 and 17:30 on ...

in order to study the effect of different levels of nitrogen and copper on yield and nutrients concentrations and nitrate in broccoli head, an experiment was conducted based on a factorial combinations of five levels of nitrogen (0, 100, 200, 300 and 400 kg/ha) and three levels of copper (0, 2.5 and 5 kg/ha) that were applied to soil as ammonium sulfate and copper sulfate respectively, in three...

improving the soil quality with organic matter content and presence of elements such as n, p and k are some of sewage sludge benefits. adjusting carbonaceous materials such as plant wastes to dewatered sludge compost increases its moisture and improves c/n ratio. so dewatered sludge has low c/n ratio and should be mixed with bulking agents. this study was performed in a three months period of t...

A novel series of meta-substituted ethanediamide and 2-butenediamide derivatives were synthesized and tested for their ability to inhibit electric eel acetylcholinesterase (AChE) and equine serum butyrylcholinesterase (BuChE). The synthesized compounds were evaluated against ChE enzymes using the colorimetric method described by Ellman et al. (Biochem. Pharmacol., 7, 1961). It was revealed that...

Zapoteca portoricensis (Jacq) HM Hernández is used with remarkable efficacy in ethnomedicinal management of tonsillitis in the Eastern part of Nigeria. Previous pharmacological studies have validated the antiinflammatory and antimicrobial activities of the crude extract. In this study, two dipeptides, saropeptate (aurantiamide acetate) and anabellamide, were isolated from the methanol root extr...

Novel enzyme-luminescence method is used for the rapid and sensitive in vitro detection of natural neurotoxins (e.g., shellfish and mushroom toxins) using model brain cells. Paralytic shellfish poisons gonyautoxins (e.g., GTX2,3 and GTX1,4) were detected at 1 nM level by their inhibition of glutamate release from C6 glioma cells upon drug stimulation (IC50: GTX2,3 = 30 nM and GTX1,4 = 8 nM). Ac...

Human acid beta-glucosidase (D-glucosyl-N-acylsphingosine glucohydrolase, EC 3.2.1.45) cleaves the beta-glucosidic bonds of glucosylceramide and synthetic beta-glucosides. The specificity of binding to the active site of this enzyme was evaluated using series of inhibitors including synthetic sphingosines, N-alkyl(Cn)-deoxynojirimycins (1,5-dideoxy-5-iminoglucose) and N-Cn-glucosylamines. The s...

This paper investigates the amount of doping concentration in silicon semiconductor using optical principle.  Both donor and acceptor impurities of n type and p-type silicon semiconductor materials are computed at wavelength of 1550 nm. During the computation of donor and acceptor impurities, both reflection and absorption losses are considered. Theoretical result showed that transmitted intens...