Even though antibiotic eluting bone cements are successfully used in orthopedic practice, adding chemotherapy drugs to bone cement pose a different set of problems. This is mainly due to the toxicity concerns associated with the use of chemotherapy agents. To avoid local or systemic toxicity, the drug elution profile of a particular bone cement/drug concentration need to be determined. The drug...

In vitro metabolic behavior was investigated for two chromium tricarbonyl derivatives of the antischistosomal drug praziquantel (PZQ) with the formula (η(6)-PZQ)Cr(CO)3 (1 and 2), by use of human liver microsomes. The metabolic profiles of the derivatives differ significantly. The optically pure (η(6)-PZQ)Cr(CO)3 derivatives (S, Sp)-1, (R, Rp)-1, (S, Rp)-2, and (R, Sp)-2 were also prepared to a...

N -body simulations predict that CDM halo-assembly occurs in two phases: 1) a rapid accretion phase dominated by major mergers with a rapidly deepening potential well; and 2) a slow accretion phase characterised by a gentle addition of mass to the outer halo with little change in the inner potential well. We demonstrate, using onedimensional simulations, that this two-phase accretion leads to C...

N -body simulations predict that CDM halo-assembly occurs in two phases: 1) a fast accretion phase with a rapidly deepening potential well; and 2) a slow accretion phase characterised by a gentle addition of mass to the outer halo with little change in the inner potential well. We demonstrate, using one-dimensional simulations, that this two-phase accretion leads to CDM halos of the NFW form an...

The etch characteristics of CoFeB magnetic films and magnetic-tunnel-junction (MTJ) stacks masked with Ti films were investigated using an inductively coupled plasma reactive ion etching in a HBr/Ar gas mix. The etch rate, etch selectivity, and etch profile of the CoFeB films were obtained as a function of the HBr concentration. As the HBr gas was added to Ar, the etch rate of the CoFeB films, ...

INTRODUCTION Cholestasis leads to liver cell death, fibrosis, cirrhosis, and eventually liver failure. Bile duct ligated rats constitute an interesting model to study the mechanism of cholestasis, and its action on several organs and tissues, including the brain. AIM To analyze brain bile acids individually in ligated rats to evaluate if its profile is altered towards a more toxic condition i...

In this paper, we describe the design of a profile generator toolkit, which aims to automatically create realistic user profiles for a mobile personalized portal service. These profiles simulate actual user behavior and are utilized to experiment with a personalized crawling system, called eRACE. With the help of this tool, we will assess the performance and scalability of the eRACE system by c...

The present study investigated the feasibility of bioCO(2) sequestration using Chlorella sorokiniana. It was found that 5% CO(2) (v/v) in air was the most suitable concentration for the growth of this organism. At this concentration, the maximum rate of CO(2) sequestered and the biomass obtained were found to be 1.21 g L(-1)d(-1) and 4.4 g L(-1) respectively. Modeling and simulation of the grow...

We provide the first direct lifting of the mass/anisotropy degeneracy for a cluster of galaxies, by jointly fitting the line of sight velocity dispersion and kurtosis profiles of the Coma cluster, assuming an NFW tracer density profile, a generalized-NFW dark matter profile and a constant anisotropy profile. We find that the orbits in Coma must be quasi-isotropic, and find a mass consistent wit...

The aim of this work was to evaluate the anti-Candida efficacy of twenty five molecules of plant origin. Based on their MICs, effective molecules were categorized into four categories. Susceptibility testing of test compounds was carried out by standard methodology (M27-A2) as per CLSI guidelines. Minimum Fungicidal Concentration (MFC) was determined as the lowest concentration of drug killing ...