Dolutegravir is neither an inducer nor inhibitor of metabolising enzymes, and it therefore has a low propensity to act as perpetrator drug-drug interactions. Clinically significant decreases in dolutegravir exposure occur when co-administered with strong inducers (e.g. rifampicin, efavirenz) drug enzymes efflux transporters for which substrate – this can be overcome by increasing the dose from ...

The current study's objective was to investigate the interactions of favipiravir with pioglitazone and citalopram. 25 Spraque-Dawley female rats were used in study. Rats groups 1 4 given (1 mg/kg/day) for 7 days 2 5 citalopram (1.5 days. 3, 4, a loading dose (50 mg/kg) on 6th day study maintenance (30 7th After last drug administration, blood samples taken from at 15, 30, 45 minutes, 1, 2, 6, 8...

INTRODUCTION Published data demonstrate a serious interaction between valproic acid and meropenem. However, recommendations about the management of concomitant treatment are contradictory; some experts recommend closer monitoring of valproic acid serum concentrations and others recommend avoiding concurrent therapy. The purpose of this study is to critically analyse the interaction and to evalu...

The article describes the main pathophysiological mechanisms underlying potential use of antirheumatic therapy in new COVID-19 patients with rheumatic diseases. Also, it summarizes current data on risk and outcome systemic autoimmune To date, there are no large randomized studies drugs diseases setting COVID-19. Besides, is convincing evidence that any disease-modifying drug (conventional synth...

Increasing use of therapeutic proteins (TPs) in polypharmacy settings calls for more in-depth understanding of the biological interactions that can lead to increased toxicity or loss of pharmacological effect. Factors such as patient population, medications that are likely to be coadministered in that population, clearance mechanisms of a TP, and concomitant drugs have to be taken into account ...

OBJECTIVE Genetic variation in drug metabolizing enzymes and membrane transporters as well as concomitant drug therapy can modulate the beneficial and the deleterious effects of drugs. We investigated whether patients exhibiting rhabdomyolysis who were taking cerivastatin possess functional genetic variants in SLCO1B1 and whether they were on concomitant medications that inhibit OATP1B1, result...

• Objective: To determine the incidence and treatment cost of oral candidiasis among patients using triamcinolone acetonide (TAA) as their only inhaled bronchial steroid (IBS) and patients using other IBS agents. • Design: A retrospective analysis was conducted using a pharmacy benefits management claims database. • Patients: Patients between 6 and 80 years of age were included in the study if ...

We report a case of probable poisoning with codeine phosphate in a 3-month-old infant, which was associated with excessive dosing and concomitant use of antihistamines. Investigation into the patient's drug history identified the recent use of a proprietary cough and cold medicine containing codeine phosphate and dexchlorpheniramine. The prescribing information, available from a popular prescri...

Purpose This study evaluates the effect of tafluprost on visual field progression in normal-tension glaucoma (NTG) in a Japanese population under daily clinical practice settings. Patients and methods This is a post-marketing, multicenter, non-interventional, observational study. Patients with NTG who initiated tafluprost treatment were registered and prospectively observed for 2-3 years to i...

Bacground/Aim. Treatment of neurological diseases usually requires polypharmacy, and it is crucial to detect potential drug-drug interactions (DDIs) recognize risk factors on time, as consequences DDIs could be serious. The aim the study was analyze for occurrence number among patients in a general ward. Methods. This conducted with 144 inpatients general-care department tertiary care hospital....