PURPOSE We investigated the retinal disease due to mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene in human patients and in an Rpgr conditional knockout (cko) mouse model. METHODS XLRP patients with RPGR-ORF15 mutations (n = 35, ages at first visit 5-72 years) had clinical examinations, and rod and cone perimetry. Rpgr-cko mice, in which the proximal promoter and first exon...

This paper presents a computational model for color coding that provides a functional explanation of how humans perceive colors in a homogeneous color space. Beginning with known properties of human cone photoreceptors, the model estimates the locations of the reflectance spectra of Munsell color chips in perceptual color space as represented in the CIE L*a*b* color system. The fit between the ...

The experimental investigation on a 60 apex-angle is carried out to study feasibility of simultaneous measurement of drag and aerodynamic heating in a shock tunnel. A three-component accelerometer balance system is used to measure the drag whereas platinum thin film gauges are used for heating rate measurements on the surface of the blunt cone model. Since every ground test and flight test data...

Carbon nanoparticles, like nanocones and nanodiscs, can be obtained by mechanical treatment of carbon nanofilaments. Microstructural studies suggest that in nanocones the conical graphene stacking with progressively increasing apex (cone) angles does not fully agree with current theoretical geometry models, such as a closed cones model and a cone-helix model. The unusual stacking form of nanoco...

BACKGROUND Mutations in the CEP290 (cilia-centrosomal protein 290 kDa) gene in Leber congenital amaurosis (LCA) cause early onset visual loss but retained cone photoreceptors in the fovea, which is the potential therapeutic target. A cone-only mouse model carrying a Cep290 gene mutation, rd16;Nrl-/-, was engineered to mimic the human disease. In the current study, we determined the natural hist...

One of the challenges of using light-cone methods 1,2 to solve nonperturbative problems in field theories such as quantum chromodynamics (QCD) is to develop a nonperturbative regularization and renormalization scheme. Here we discuss a new approach 3,4 based on generalized Pauli–Villars regularization 5 and discretized light-cone quantization (DLCQ). The DLCQ Fock basis is expanded to include m...

Cone signals in the luminance or achromatic pathway were investigated by measuring how the perceptual timing of M- or L-cone-detected flicker depended on temporal frequency and chromatic adaptation. Relative timings were measured, as a function of temporal frequency, by superimposing M- or L-cone-isolating flicker on "equichromatic" flicker (flicker of the same wavelength as the background) and...

PURPOSE To identify individual cone photoreceptors in a transgenic mouse line in vivo based on selective expression of green fluorescent protein (GFP) using cSLO (confocal scanning laser ophthalmoscopy) and to use this approach to monitor cone cell fate in mouse models of retinal degeneration. METHODS Transgenic mice expressing GFP under the control of a red-green opsin promoter (RG-GFP mice)...

in this paper, we prove the existence of fixed point for chatterjea type mappings under $c$-distance in cone metric spaces endowed with a graph. the main results extend, generalized and unified some fixed point theorems on $c$-distance in metric and cone metric spaces.

The lack of interoperability between information systems that support design and manufacturing is known as one of the major open issues in the field of Product Lifecycle Management. Especially, the BOM transfer between PDM and ERP suffers from a lack of consistent model that would enable a conservative propagation of updated information from one system to the other. This paper introduces a mini...