Higher visual functions were investigated in patients treated for bilateral congenital cataracts in two experiments. Participants were asked to detect either real or illusory contours (Kanizsa squares in Experiment 1 or one of four different Kanizsa contours in Experiment 2) among distractor items. Compared to normally sighted participants matched for age, gender and education, cataract patient...

Paediatric Association [7] currently recommend red reflex assessment as a component of the eye evaluation in the neonatal period and during all subsequent routine health supervision visits. The purpose of this policy statement is to minimize the risk of delay in the diagnosis of serious vision-threatening or life-threatening disorders. Despite these worldwide recommendations, there are large va...

PURPOSE To investigate a novel deletion variant of gammaD-crystallin (CRYGD) identified in a Chinese family with nuclear congenital cataract. METHODS A Chinese family with five affected members diagnosed with nuclear cataract and four unaffected members were recruited for the mutational screening of 15 known candidate genes for autosomal dominant congenital cataract. Two-point linkage analysi...

INTRODUCTION Mal de Meleda is a rare form of palmoplantar keratoderma, with autosomal recessive transmission. It is characterized by diffuse erythema and hyperkeratosis of the palms and soles. Recently, mutations in the ARS (component B) gene (ARS, MIM: 606119) on chromosome 8q24.3 have been identified in families with this disorder. Congenital cataract is a visual disease that may interfere wi...

Purpose To assess the outcome of cataract surgery with hydrophilic acrylic intraocular lens (IOL) implantation in children with congenital and developmental cataracts. Method A retrospective review of medical records of children with congenital or developmental cataracts who underwent cataract surgery with hydrophilic IOL implantation, from January 2011 to December 2014 in a tertiary eye hosp...

PURPOSE To screen α-crystallin (CRYAB), γ-crystallin (CRYGC and CRYGD), and Connexin 50 (Cx-50 or GJA8) genes in congenital cataract patients and controls. METHODS Thirty clinically diagnosed congenital cataract cases below 3 years of age from northern India, presenting at Dr. R. P. Centre for Ophthalmic Sciences (AIIMS, New Delhi, India) were enrolled in this study. Genomic DNA was extracted...

Functional brain development is characterized by sensitive periods during which experience must be available to allow for the full development of neural circuits and associated behavior. Yet, only few neural markers of sensitive period plasticity in humans are known. Here we employed electroencephalographic recordings in a unique sample of twelve humans who had been blind from birth and regaine...

PURPOSE To evaluate the ocular axial length (AL) and keratometry (K) in Brazilian children with congenital/developmental cataract, assess the differences and evolution of AL and K according to age, and establish functional models of AL and K as function of age. METHODS Children with congenital/developmental cataract aged 1.5 months old to 8 years old and no other ocular diseases were included...

CONTEXT Bilateral pediatric cataracts are important cause of visual impairment in children. AIM To study the outcome of bilateral pediatric cataract surgery in young children. SETTING AND DESIGN Retrospective case series in a tertiary center. MATERIALS AND METHODS Records of pediatric cataracts operated between January 2001 and December 2003, with a minimum follow-up of 3 months, were rev...

OBJECTIVES To report the incidence of glaucoma and glaucoma suspects in the IATS, and to evaluate risk factors for the development of a glaucoma-related adverse event in patients in the IATS in the first year of follow-up. METHODS A total of 114 infants between 1 and 6 months of age with a unilateral congenital cataract were assigned to undergo cataract surgery either with or without an intra...