BACKGROUND It is a widely held view that congenital heart block (CHB) is caused by the transplacental transfer of maternal autoantibodies (anti-SSA/Ro and/or anti-SSB/La) into the fetal circulation. To test this hypothesis and to reproduce human CHB, an experimental mouse model (BALB/c) was developed by passive transfer of human autoantibodies into pregnant mice. METHODS AND RESULTS Timed pre...

OBJECTIVE This article aims to present updated therapeutic options for fetal congenital heart diseases. METHODS Data source for the present study was based on comprehensive literature retrieval on fetal cardiac interventions in terms of indications, technical approaches and clinical outcomes. RESULTS About 5% of fetal congenital heart diseases are critical and timely intrauterine interventi...

we report a unique case of chronic dissection of the ascending aorta complicated with huge and thrombotic pseudoaneurysm in a patient with coarctation of descending aorta. preoperative investigations such as transesophageal echocardiography (tee) confirmed the diagnosis of dissection. intraoperative findings included a12 cm eccentric bulge of the right lateral side of dilated the ascending aort...

the aim of this study is to evaluate early and late results of surgery in children with congenital heart disease and decreased pulmonary blood flow, who underwent a palliative systemic-to-pulmonary shunt. during the past 9 years, 157 systemic-to-pulmonary artery shunts were performed in 130 patients (69 males, 61 females) with ages from 1 day to 31 years old. they had been evaluated for their c...

discussion children with congenital heart disease are at risk of acquiring gram-negative endocarditis even if they have not had other predisposing factors. case presentation in this study a ten-year-old boy with ventricular septal defect, who was not immune compromised and acquired klebsiella endocarditis is introduced. the patient had a favorable response to medical treatment and underwent a s...

conclusions the results of this study indicated that pmv predictors could be specific for each center and a good administration program is needed for each pediatric cardiac surgery center for the preoperative management of patients undergoing congenital heart surgeries. results a total of 300 patients, 56.7% male, were enrolled in this study. their mean age was 32 ± 40 months .the median durati...