Regioselective reaction of a lithium organocuprate (R2CuLi) and a polyconjugated carbonyl compound affords a remote-conjugate-addition product. This reaction proceeds particularly cleanly when the conjugation is terminated by a C-C triple bond. The reaction pathways and the origin of the regioselectivity of this class of transformations are explored with the aid of density functional calculatio...

The direct nucleophilic addition of alkyl amines to the α(δ')-carbon atom of dimethyl (E)-hex-2-en-4-ynedioate to generate α,β-dehydroamino acid derivatives is reported. Herein, we have studied the reactivity of various primary and secondary alkyl amines in the α-selective nucleophilic conjugate addition to conjugated dimethyl (E)-hex-2-en-4-ynedioate. The reaction with primary alkyl amines giv...