Beta-lactamases confer bacterial resistance to beta-lactam antibiotics, such as penicillins. The characteristic class C beta-lactamase AmpC catalyzes the reaction with several key residues including Ser64, Tyr150, and Lys67. Here, we describe a 1.07 A X-ray crystallographic structure of AmpC beta-lactamase in complex with a boronic acid deacylation transition-state analogue. The high quality of...

A functional ovalbumin-dextran conjugate was prepared by dry-heated storage at 60 degrees C and 65% relative humidity for 3 weeks. The emulsifying properties of the ovalbumin-dextran conjugate were about three times higher than those of an ovalbumin-glucose conjugate. SDS-electrophoresis patterns showed that the ovalbumin-dextran conjugate obtained by dry-heating was not as polydispersed as tha...

abstract many studies have been conducted on the characteristics of hydraulic jump over gradually expanding cross sections, but comparatively few have been carried out on basins with convergent wall. in the present research, the hydraulic jump characteristic of the stilling basin with convergent wall has been investigated. the main objective of this research is evaluation of conjugate depths ra...

background: measurement of absolute or differential renal function using radiotracers plays an important role in the clinical management of various renal diseases. gamma camera quantitative methods in approximation of renal clearance may potentially be as accurate as plasma clearance methods. however some critical factors such as kidney depth and background counts are still troublesome in the u...

the falling and settling of solid particles in gases and liquids is a natural phenomenon happens in many industrial processes. this phenomenon has altered pure forced convection to a combination of heat conduction and heat convection in a flow over a plate. in this paper, the coupling of conduction (inside the plate) and forced convection of a non-homogeneous nanofluid flow (over a flat plate) ...

cystic hydatid disease is caused by cystic larval (metacestode) stages of echinococcus granulosus. this parasite can potentially occur all over the world especially in mediterranean and middle east countries and some parts of africa, latin america and china which have major foci of human infections. the cyst wall of metacestodes consists of inner, middle and external layers. to date, little att...

to improve the accuracy of the activity quantification and the image quality in scintigraphy, scatter correction is a vital procedure. the aim of this study is to compare the accuracy in calculation of absorbed dose to patients following bone scan with 99m tc-marked diphosphonates ( 99m tc-mdp) by two different methods of background correction in conjugate view method. this study involved 22 pa...

Attachment of a nondiffusible bromoacetyl electrophile to the 5-position of a thymine at the 5'-end of a pyrimidine oligodeoxyribonucleotide affords sequence-specific alkylation of a guanine base in duplex DNA two base pairs to the 5'-side of a local triple-helical complex. Products resulting from reaction of 5'-ETTTTMeCTTTTMeCMeCTTTMeCTTTT-3' at 37 degrees C with a 29 base pair target duplex a...

A min-max formula is proved for the minimum of an integer-valued separable discrete convex function in which taken over set integral elements a box total dual polyhedron. One variant theorem uses notion conjugate (a fundamental concept nonlinear optimization), but we also provide another version that avoids conjugates, and its spirit conceptually closer to standard form classic theorems combina...