Optical breast imaging studies show that controlled pressure maneuvers improve contrast between tumors and both the surrounding healthy tissue and the contralateral breast. The accuracy of tumor localization and sizing was consequently improved. OCIS codes: (170.3830) Mammography; (170.2655) Functional monitoring and imaging; (120.5475) Pressure measurement

Hypermethylated genes are emerging as some of the most promising, practical and powerful biomarkers for breast cancer detection and perhaps even of risk assessment. We have assembled a panel of methylated gene detection markers and tested them by Quantitative Multiplex Methylation-Specific PCR (QM-MSP) in breast cancer. Here we two pilot studies: 1) detection of cancer in DNA from spontaneous n...

Malignant vascular tumors are rare and angiosarcomas of the breast in patients under 21 years of age are exceedingly uncommon. In this report an angiosarcoma in the breast of a 14-year-old girl is described. She died nine months after mastectomy with recurrent disease in the bones and the contralateral breast. The etiology of most primary angiosarcomas is unknown. Secondary angiosarcomas can de...

This review paper analyzed publications of adjuvant tamoxifen and aromatase inhibitor use following surgery for breast ductal carcinoma in situ (DCIS). Key endpoint analyses were risk of invasive and noninvasive malignancies and new contralateral breast cancers. Metaanalysis of three studies showed a relative risk of 0.69 (95% confidence interval, 0.60-0.79, P<0.05) for breast malignancies with...

Introduction: Breast conserving surgery followed by adjuvant radiotherapy (RT) of the whole breast is accepted as the treatment of choice in early stage breast cancer. Due to breast irregularities, it is difficult to access homogenous dose distribution with conventional techniques. Currently, it is possible to use varied breast irradiation techniques, such as field- in-field (F...

Introduction: Single isocentre half-beam block (HBB) technique permits the avoidance of hot and cold spots. This technique is very useful in sparing the underlying ipsilateral lung and heart, if the left breast is treated. The major advantage of this technique is that it facilitates the complete sparing of both contralateral breast and lung. Regarding this, the present study aimed to analyse th...