One of the newest and yet fastest growing indications for dietary therapy is the emergency treatment of refractory status epilepticus. Ten retrospective publications since 2008 have reported benefits in 32 children and adults, of whom 25 (78%) became seizure-free. Most of the patients who responded did so within 7 to 10 days of the initiation of nasogastrically administered ketogenic formulas. ...

ing clinical seizures in epileptic patients [2]. In a volume supposedly designed to help physicians elucidate the recognition of pseudoseizures, such misleading oversimplification serves the opposite cause. The patient was better off before his doctor read this book. To be fair, certain chapters are well written and address their topic beautifully (Desai, Lesser, Ehrenberg). The concept of such...

Status epilepticus, meaning either continuous convulsions with unconsciousness or serial epileptic attacks, between which there is no return to consciousness, is always a serious and potentially fatal emergency. It is of special importance in paediatrics, for infants and young children have a lower convulsive theshold than adults, and recent work (Ounsted, Lindsay, and Norman, 1966) has indicat...

Previous studies reported that the proline-rich transmembrane protein 2 (PRRT2) gene was identified to be related to paroxysmal kinesigenic dyskinesia (PKD), infantile convulsions with PKD, PKD with migraine and benign familial infantile epilepsy (BFIE). The present study explores whether the PRRT2 mutation is a potential cause of febrile seizures, including febrile seizures plus (FS+), general...

PURPOSE We aimed to investigate the frequency of incomplete hippocampal inversion (IHI) and the hippocampal infolding angle (HIA) in pediatric patients with no additional abnormal findings in the brain. METHODS Pediatric brain magnetic resonance imaging (MRI) examinations conducted between September 2012 and February 2015 were screened and 83 patients with epilepsy, 49 patients with febrile c...

background: carum carvi l . (caraway), known as black zeera in iran, has been indicated for the treatment of epilepsy in iranian folk medicine. this study evaluated whether the aqueous extract and essential oil of caraway seeds have anticonvulsant effects in mice. methods: the anticonvulsant effects of the aqueous extract (200, 400, 800, 1600, and 3200 mg/kg, i.p.) and essential oil (25, 50, 10...

It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critical time window. Postnatal administered IL-1β alone mimicked the effect of FS on adult seizure susc...

Postictal values of plasma prolactin levels were measured in 15 children with generalized seizures, 8 children with pseudoseizures and 6 control subjects. In patients with generalized seizure, the mean plasma prolactin level was 28.6 +/- 2.3 ng/ml, whereas in patients with pseudoseizures and in controls, its mean values were 10.4 +/- 3.8 ng/ml and 9.8 +/- 2.6 ng/ml, respectively. Thus, prolacti...

BACKGROUND Lead elements have an adverse effect on human health. The most important complications of lead poisoning are disorders of nervous system particularly seizure .This study aimed to evaluate the blood lead levels and its association with convulsion in a group of hospitalized febrile children. METHODS In this analytic cross-sectional study, 60 hospitalized febrile children with 1- 60 m...

Epilepsy is estimated to affect 1-2% of the world population, yet remains poorly understood at a molecular level. We have previously established the roundworm Caenorhabditis elegans as a model for investigating genetic susceptibilities to seizure-like convulsions in vivo. Here we investigate the behavioral consequences of decreasing the activity of nematode gene homologs within the LIS1 pathway...