PURPOSE Central corneal thickness (CCT) exhibits broad variability. For unknown reasons, CCT also associates with diseases not typically considered corneal, particularly glaucoma. The purpose of this study was to test the strain dependence of CCT variability among inbred mice and identify cellular and molecular factors associated with differing CCT. METHODS Methodology for measuring murine CC...

BACKGROUND The baseline data pertaining to the national epidemiological survey of infectious keratitis remain scarce in China, and currently there is no corneal blindness control strategy developed by the nation. METHODS Geographically defined cluster sampling was used to randomly select a cross-section of residents from representative urban and rural populations in Hubei Province. Participan...

PURPOSE Because of its unique characteristics, the cornea has been widely used for blood and lymphatic vessel research. However, whether limbal or corneal vessels are evenly distributed under normal or inflamed conditions has never been studied. The purpose of this study was to investigate this question and to examine whether and how the distribution patterns change during corneal inflammatory ...

PURPOSE To analize changing trends in indications and surgical techniques of corneal transplantation at an ophthalmological tertiary referral center in Colombia over a 7 year period. METHODS A retrospective analysis was performed of medical records from patients who underwent corneal transplantation surgeries at Fundación Oftalmológica de Santander (FOSCAL) in Bucaramanga, Colombia, between A...

Dexpanthenol – a precursor to vitamin B5 is compound of natural origin that has long-known beneficial effect on skin and mucous membrane hydration epithelial healing. Its anti-inflammatory activity also used in treatment. effects superficial tissues have been observed numerous vitro vivo studies, but the exact mechanism action not yet understood. In ophthalmology, dexpanthenol well-known widely...

the objectives of this study were to define the clinical risk factors, microbiological spectrum, and visual outcome of bacterial keratitis at shahid sadoughi hospital (yazd, iran). a crosssectional prospective study, identified 80 cases of microbial keratitis from march 1999 to march 2001. inclusion criteria were presence of corneal stromal infiltrate in slit lamp examination, and microbiologic...

PURPOSE To investigate the effects of insulin and leptin on in vitro wound healing of transformed human corneal epithelial cell monolayers and to identify cellular (migration versus proliferation) and intracellular signaling mechanisms. METHODS Scratch wounds were created in monolayers of an immortalized human corneal epithelial cell (HCEC) line. The wounded monolayers were exposed to insulin...

During the course of experiments examining the immunobiology of corneal transplants, the corneas of athymic, nude mice (nu/nu) were found to contain blood vessels that extended through the entire superficial stroma into the centermost portion of the cornea. The presence of corneal vessels was not related to the immunodeficient condition of the nude mouse since corneas from the severe combined i...

Neurotrophic keratitis (NK) is a degenerative disease characterized by corneal sensitivity reduction, spontaneous epithelium breakdown, and impairment of corneal healing. Several causes of NK, including herpetic keratitis, diabetes, and ophthalmic and neurosurgical procedures, share the common mechanism of trigeminal damage. Diagnosis of NK requires accurate investigation of clinical ocular and...

Corneal polarimetry measurement has been the object of several papers. The results of techniques like polarization-sensitive optical coherence tomography (PS-OCT), scanning laser polarimetry, or polarization microscopy are contradictory. Some studies propose a biaxial-like birefringence pattern, while others postulate that birefringence grows at corneal periphery. Several theoretical approaches...