AIMS The aim of the present study was to evaluate the cicatricial repair of a corneal artificial perforation in rats with 10-0 nylon suture, N-butyl-2-cyanoacrylate (NBCA) adhesive, or NBCA + methacryloxysulfolane (NBCA-MS) adhesive through microscopic and histological assays. METHODS Twenty Wistar rats were randomly divided into 4 groups each containing 5 rats: (1) control group (corneal tra...

The cornea requires constant epithelial renewal to maintain clarity for appropriate vision. A subset of stem cells residing at the limbus is primarily responsible for maintaining corneal epithelium homeostasis. Trauma and disease may lead to stem cell deficiency and therapeutic targeting to replenish the stemness capacity has been stalled by the lack of reliable corneal epithelial stem cell mar...

RATIONALE Erlotinib, an antineoplastic agent, is indicated for the treatment of patients with advanced nonsmall cell lung cancer. Most common adverse events are manageable, although more severe ones require dose reduction or discontinuation of erlotinib treatment. PATIENT CONCERNS We present a case of severe corneal ulcer treated with autologous plasma rich in growth factors. DIAGNOSES A 76...

Neurotrophic keratitis (NK) is a degenerative disease characterized by corneal sensitivity reduction, spontaneous epithelium breakdown, and impairment of corneal healing. Several causes of NK, including herpetic keratitis, diabetes, and ophthalmic and neurosurgical procedures, share the common mechanism of trigeminal damage. Diagnosis of NK requires accurate investigation of clinical ocular and...

BACKGROUND To report a case of keratitis and a case of conjunctivitis caused by synthetic fibers from toy teddy bears. CASE PRESENTATION Case stories with histopathological analysis. 1) A two-year-old girl developed a severe case of keratitis and corneal ulceration. The initial treatment with various antibiotics gave no improvement and eventually the patient developed spontaneous perforation ...

PURPOSE To report a case of corneoscleral melt that occurred 50 years after resection of pterygium with postoperative administration of mitomycin C (MMC). RESULTS A 93-year-old woman developed acute corneal perforation and scleral melt in her left eye at 50 years after pterygium surgery with postoperative topical MMC. She underwent limbal transplantation. The anterior chamber reformed postope...

PURPOSE To review the most commonly encountered laser in situ keratomileusis (LASIK) microkeratome-related complications, and the most up-to-date methods in their prevention and treatment. METHODS A review of microkeratome-related complications including epithelial complications, bleeding, thin flap, button hole, free cap, incomplete pass, and corneal perforation was conducted. The most recen...

PURPOSE To investigate the microbial isolates from patients with ocular infections and the trend in the emergence of levofloxacin-resistant strains over the past four years from 2006 to 2009 retrospectively. PATIENTS AND METHODS The subjects were 242 patients with ocular infections or traumas treated in our hospital including outpatients, inpatients, and emergency room patients. Most of them ...

A 66-year-old man with ectodermal dysplasia syndrome, right eye Type 1 Boston Keratoprosthesis (K-Pro), and chronic angle-closure glaucoma underwent cyclophotocoagulation diode in the (2500 mW, 2-4 seconds), which resulted scleral perforation 3 Seidel positive holes along inferotemporal limbus (Fig A). LiquiBand glue was applied perforations were covered a Tutoplast patch graft followed by amni...

microbial corneal diseases are a serious ocular infection and the major cause of ocular morbidity and blindness in the world. the outcomes of fungal keratitis are unfavorable due to the protracted course of the condition and the diversity of respective clinical presentations. trauma, contact lens wear, foreign material, and prior corneal surgery, may make the most background for permitting inva...