Steroid hormones are important regulators of a wide variety of reproductive and behavioral functions. We investigated the ability to track sex steroids and glucocorticoids in urine samples collected noninvasively from pre- and postpartum female baboons. Paired plasma and urine samples were collected every 2 weeks prior to and following birth in 10 females. Changes in concentrations of plasma st...

BACKGROUND AND METHODS Quantitative enzyme-immunoassays of urinary and fecal immunoglobulin A (IgA), cortisol and 11-17-dioxoandrostanes (11,17-DOA), and serum cortisol in eight metabolic-cage-housed female cynomolgus monkeys were performed. The monkeys were divided into two groups, B and NB. Group B animals were blood sampled every 6 hours, whereas Group NB animals were not handled/blood sampl...

Glucocorticoids (GCs) are one of the most effective anti-inflammatory drugs for treating acute and chronic inflammatory diseases. However, several studies have shown that GCs alter collagen metabolism in the skin and induce skin atrophy. Cortisol is the endogenous GC that is released in response to various stressors. Over the last decade, extraadrenal cortisol production in various tissues has ...

Environmental changes result in physiological responses of organisms, which can adversely affect population dynamics and reduce resistance to disease. These changes are expressed in chronic levels of stress. The measurement of glucocorticoid (GC) concentrations in faeces is a non-invasive method for monitoring stress in wildlife. The metabolism and excretion of steroids differ significantly bet...

A Western-type diet is associated with osteoporosis and calcium nephrolithiasis. On the basis of observations that calcium retention and inhibition of bone resorption result from alkali administration, it is assumed that the acid load inherent in this diet is responsible for increased bone resorption and calcium loss from bone. However, it is not known whether the dietary acid load acts directl...

UNLABELLED BACKGROUND Residual alcohol effects on physiological and psychological symptoms are commonly experienced the morning after alcohol consumption. The purpose of this study was to assess the effects of L-ornithine on subjective feelings and salivary stress markers the morning after alcohol consumption and to investigate whether L-ornithine acutely accelerates ethanol metabolism. ME...

The composition of human milk is subject to considerable variation, but the effects maternal stress are largely unknown. We studied differences in metabolome between Finnish mothers (n = 120, secretors) with symptoms prenatal psychological distress and cortisol concentrations. Human samples acquired at 2.5 months postpartum were analyzed using targeted 1H NMR metabolomics. Self-reported scores ...

Background: High altitude exposure triggers a series of physiological changes to maintain homeostasis. Although longer-term (days years) acclimatization processes are well studied, less is known about the upon rapid ascent. We took advantage Peru’s geography measure first following transport from low high-altitude environment among lowlanders. <ns4:bol...

Background Coronavirus disease 2019 (COVID-19) has permanently changed the world. Despite having been a pandemic for nearly 3 years, mid- and long-term complications of this disease, including endocrine disorders, remain unclear. Our study aimed to evaluate lasting effects COVID-19 on system 6 months after initial infection. Methods We compared patients who underwent age- sex-matched subjects f...