BACKGROUND A Centenarian is a person who attains and lives beyond the age of 100. Four percent of centenarians die from cancer. It is therefore important to understand which cancers affect them in order to devise better methods to prevent and treat them. The aim of this study was to investigate the top cancers that affect centenarians. MATERIAL AND METHODS We identified 1385 cases with the Su...

Introduction: Iran experienced a dramatic fertility decline during recent decades. There was also an indication of a shift towards later childbearing from 2000. Past research on fertility has shown that the education variable is the most important determinant of fertility behaviors. However, the impact of education on fertility timing in Iran has been less considered. Methods: In a cross secti...

This paper proposes the Additive Risk Model (ARM), first used by Aalen (1980), to explain households’ interpurchase times. Unlike the Proportional Hazard Model (PHM), first proposed by Cox (1972), the ARM incorporates the effects of covariates on the individual hazard function in an additive (as opposed to multiplicative) manner. While a large number of previous studies on interpurchase timing ...

The association of hemodialysis dosage with patient survival is controversial. Here, we tested the hypothesis that methods for survival analysis may influence conclusions regarding dialysis dosage and mortality. We analyzed all-cause mortality by proportional hazards and accelerated failure time regression models in a cohort of incident hemodialysis patients who were followed for 9 yr. Both mod...

BACKGROUND Oxidative stress plays an underlying pathophysiologic role in the development of diabetes complications. The aim of this study was to investigate peroxiredoxin 4 (Prx4), a proposed novel biomarker of oxidative stress, and its association with and capability as a biomarker in predicting (cardiovascular) mortality in type 2 diabetes mellitus. METHODS Prx4 was assessed in baseline ser...

BACKGROUND It has been proposed that bipolar disorder onsets in a predictable progressive sequence of clinical stages. However, there is some debate in regard to a statistical approach to test this hypothesis. The objective of this paper is to investigate two different analysis strategies to determine the best suited model to assess the longitudinal progression of clinical stages in the develop...

BACKGROUND Predicting the risk of recurrent venous thromboembolism (VTE) in an individual patient is often not feasible. We aimed to develop a simple risk assessment model that improves prediction of the recurrence risk. METHODS AND RESULTS In a prospective cohort study, 929 patients with a first unprovoked VTE were followed up for a median of 43.3 months after discontinuation of anticoagulat...

Background—Predicting the risk of recurrent venous thromboembolism (VTE) in an individual patient is often not feasible. We aimed to develop a simple risk assessment model that improves prediction of the recurrence risk. Methods and Results—In a prospective cohort study, 929 patients with a first unprovoked VTE were followed up for a median of 43.3 months after discontinuation of anticoagulatio...