fibrous dysplasia (fd) is an osseous growth dis-order, producing immature bone and characte-rized by the replacement of normal bone with fibro-osseous connective tissue. it is a bone dys-plasia that has the potential to cause significant cosmetic and functional disturbances, particularly in the craniofacial skeleton. cra-niofacial fibrous dysplasia is one of the three types of polyostotic fibro...

Definition of Deformity Evaluation of Lower Limb Deformities Indications for Correction of Lower Limb Deformities Preoperative Planning Planning the Level of Osteotomy Other Factors in Determining the Level of the Osteotomy Determining the True Plane of the Deformity Translation Deformities . Angulation/Translation Deformities Multi-Apical Angular Deformities Joint Laxity Deformities of the Kne...

The pathogenesis of cleidocranial dysplasia (CCD) as well as the specific role of core binding factor β (Cbfβ) and the Runt-related transcription factor (RUNX)/Cbfβ complex in postnatal skeletogenesis remain unclear. We demonstrate that Cbfβ ablation in osteoblast precursors, differentiating chondrocytes, osteoblasts, and odontoblasts via Osterix-Cre, results in severe craniofacial dysplasia, s...

Craniofacial deformities caused by congenital defects or trauma remain challenges for clinicians, whereas current surgical interventions present limited therapeutic outcomes. Injection of bone marrow-derived mesenchymal stem cells (BMSCs) into the defect is highly desirable because such a procedure is microinvasive and grafts are more flexible to fill the lesions. However, preventing hypertroph...

The craniofacial skeleton is a complex and unique structure. The perturbation of its development can lead to craniofacial dysmorphology and associated morbidities. Our ability to prevent or mitigate craniofacial skeletal anomalies is at least partly dependent on our understanding of the unique physiological development of the craniofacial skeleton. Mouse models are critical tools for the study ...

synophthalmia is a form of cyclopia, in which some elements of two eyes are fused and form a single eye in the middle region of the forehead. the head of a holstein female calf born from a 5-year-old cow was referred to department of pathology, school of veterinary medicine, shahrekord university due to multiple congenital anomalies. the calf had been slaughtered immediately after birth due to ...