Introduction The concentration of substances, including urea, creatinine, and uric acid, can be used as an index to measure toxic uremic solutes in the blood during dialysis and interdialytic intervals. The on-line monitoring of toxin concentration allows for the clearance measurement of some low-molecular-weight solutes at any time during hemodialysis.The aim of this study was to determine the...

Background: Hypertension is one the most common causes of chronic kidney disease (CKD). One of the major concerns in hypertensive patients is early detection of renal disorders. In the past, serum creatinine (Scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated lipocal...

Our kidneys maintain a constant internal environment and circulatory volume through a combination of filtration, selective reabsorption and secretion, and production of several key hormones. Young, healthy individuals filter 100 L of blood each day; however, their kidneys then reabsorb most of this for a mean urine output of only 1.5 L/day. This filtration process is necessary to eliminate bypr...

Some time ago, in a preliminary communication1 dealing with various aspects of the distribution of creatinine and creatine in blood, we reported that the concentration of each of these substances was nearly the same, at) parturition, in the placental as in the maternal plasma, and we concluded that there takes place between the mother and the fetus a ready interchange of both. If we have hesita...

Measuring serum creatinine is cheap and commonly done in daily practice. However, interpretation of serum creatinine results is not always easy. In this review, we will briefly remind the physiological limitations of serum creatinine due notably to its tubular secretion and the influence of muscular mass or protein intake on its concentration. We mainly focus on the analytical limitations of se...

Several cephalosporin antibioticscephalothin, cephaloglycine, cephaloridine, cephacetrile, and cefoxitinreportedly interfere positively with measurement of creatinine by the Jaff#{233} reaction. Others such as cefazolin, cephalexin, cephradine, cefamandole, and cephalpirin give negative or only very slight responses under the same in vitro conditions (1, 2). Rankin et al. (3) showed in vivo int...