BACKGROUND In the last decade the frequency of celiac disease diagnosis has increased in adults. OBJECTIVES To determine disease prevalence (including silent and potential disease) in this population group. METHODS We performed serologic screening of celiac disease in a representative and homogenous sample of a young adult general population in Israel, namely, 18 year old military conscript...

Previous genome-wide expression studies have highlighted distinct gene expression patterns in inflammatory bowel disease (IBD) compared to control samples, but the interpretation of these studies has been limited by sample heterogeneity with respect to disease phenotype, disease activity, and anatomic sites. To further improve molecular classification of inflammatory bowel disease phenotypes we...

16 INTRODUCTION Crohn’s disease (CD) is a chronic inflammatory disease of the intestines without a known etiology or a cure. Similarities between Crohn’s disease and Johne’s disease, a mycobacterial infection of cattle, were first observed nearly one hundred years ago (1). There are over 100 species within the mycobacteria genus. Most are ubiquitous in soil and water, and, with the exception of...

Background and Aims Vitamin D deficiency is common in patients with Crohn's disease and is associated with disease activity. Relationship between vitamin D and endoscopic disease activity is unknown. The aim of the study is to determine the association between vitamin D status and endoscopic disease activity in CD patients. Methods Consecutive hospitalized CD patients from 2014 to 2016 who re...

BACKGROUND Celiac disease (CD) may be associated with other immunologic disorders in adults and children. Previous studies linking CD and autoimmune thyroid disease in children have included very few patients with limited biochemical and immunologic screening tests. The aim of this multicenter study was to establish the prevalence of autoimmune thyroid involvement in a large series of pediatric...

BACKGROUND Crohn's disease (CD) is a pathologic condition with different clinical expressions that may reflect an interplay between genetics and environmental factors. Recently, it has been highlighted that three genetic markers, NOD2, MHC and MST1, were associated to distinct CD sites, supporting the concept that genetic variations may contribute to localize CD. Genetic markers, previously sho...

Chagas disease (CD) is very prevalent in South America, with wellknown manifestations in the digestive system. CD esophagopathy leads to a clinical and manometric picture similar to idiopathic (primary) achalasia. Although the treatment for CD esophagopathy is well established, South American surgeons and gastroenterologists are sometimes faced with CD patients without esophageal involvement bu...

The coexistence of Crohn’s disease (CD) and autoimmune thyroid diseases [Graves’ disease (GD) and Hashimoto’s thyroiditis (HT)] is uncommon, although these conditions involve autoimmune processes. This report reviews the English and Japanese literature, including proceedings regarding coexisting CD and the autoimmune thyroid diseases GD and HT, and discusses cases of concomitant CD and GD (six ...

Recent genome-wide association studies have rapidly improved our understanding of the molecular pathways leading to inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC). Although several reports have demonstrated that gene single nucleotide polymorphisms (SNPs) are associated with susceptibility to IBD, its precise genetic factors have not been fully...

Celiac disease (CD) is a systemic immune-mediated disorder triggered by dietary gluten in genetically predisposed individuals. The typical symptoms are anemia, diarrhea, fatigue, weight loss, and abdominal pain. CD has been reported in patients with primary sclerosing cholangitis, primary biliary cholangitis, autoimmune hepatitis, aminotransferase elevations, nonalcoholic fatty liver disease, h...