BACKGROUND The deceased donor organ shortage has forced surgeons to implement innovations, including living-related liver transplantation (LRLT). OBJECTIVE To present the first 20 cases of adult LRLT in a single center in Saudi Arabia. METHODS From November 2000 to May 2004, we performed 20 cases of LRLT. Eighteen donors were men and 2 were women. Their median age was 27 years. Seventeen of...

Fatty liver has become the most common liver disorder and is recognized as a major health burden in the Western world. The causes for disease progression are not fully elucidated but lysosomal impairment is suggested. Here we evaluate a possible role for lysosomal acid lipase (LAL) activity in liver disease. To study LAL levels in patients with microvesicular, idiopathic cirrhosis and nonalcoho...

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Carcinoembryonic antigen (CEA) was measured in whole serum and in serum extracted with perchloric acid by microradioimmunoassay in patients with benign and malignant diseases of the liver and pancreas. The level of detectability was 5 ng per ml. This level or greater was present in the serum of 50% of patients with chronic diffuse liver disease, 64% with pancreatitis, 94% with cancer of the dig...

Non-alcoholic fatty liver disease (NAFLD) is an important complication of the metabolic syndrome, which is becoming an increasingly common cause of chronic liver disease. Histological changes typically mainly affect perivenular regions of the liver parenchyma and include an overlapping spectrum of steatosis, steatohepatitis and persinusoidal or pericellular fibrosis, in some cases leading to ci...

PURPOSE An increasing number of women with cirrhosis are conceiving and carrying their pregnancies to term. However, the maternal mortality rate remains high (10-61%). This case report describes the management of a parturient with esophageal varices and thrombocytopenia. She was also a Jehovah's Witness. CLINICAL FEATURES A 25-yr-old Jehovah's Witness parturient with portal hypertension and e...

ALTHOUGH its histological features had long been recognized (1). the term non-alcoholic steatohepatitis (NASH) was first used by Ludwig et al. as recently as 1980 (2). Although it is commonly encountered in hepatology outpatient (office) practice (3). surprisingly little attention has been paid to NASH. It will be the purpose of this review to examine the clinical and pathological features of N...

THE belief that an immunological mechanism is involved in the chronic inflammatory process in the liver led to the use of corticotrophin and corticosteroid therapy for active chronic hepatitis as early as the 1950's (Waldenstrom 1950, Bearn, Kunkel and Slater 1956, Mackay, Taft and Cowling, 1956). However disagreement over the indications for treatment, doubts about its real value and concern a...

background digestive and liver diseases (ld) are among the most common causes of mortality and morbidity in iran and throughout the world. we have aimed to report the etiology and outcome of gastrointestinal and ld that needed admission in a typical tertiary referral hospital in tehran during the last decade. methods shariati hospital gastroenterology and liver disease department (gi & ld) was ...

BACKGROUND Clinical and endoscopic features of cirrhotic patients with nonvariceal upper gastrointestinal bleeding (NVUGIB) have been rarely reported and clinical outcomes and predictors of mortality have not been evaluated. AIMS 1) To describe the clinical features; 2) To define the clinical outcomes; and 3) To identify the predictors of in-hospital mortality of cirrhotic patients with NVUGI...