The aim of this study was to examine the controversial effects of experimental unilateral cryptorchidism and subsequent orchiopexy on the number of germ cells and other morphometric characteristics of testicular and epididymal structures in adult rabbits. Unilateral cryptorchidism was induced in 11 mature male New Zealand white rabbits by returning one testis, together with the ipsilateral epid...

Patients with 45,X0/46XY karyotype often present with intersex phenotype and testicular dysgenesis. These patients may also have undescended testes (cryptorchidism), hypospadias and their spermatogenesis is severely disrupted. They have a high risk for testicular cancer. These patients have the most severe form of testicular dysgenesis syndrome (TDS). We have hypothesized that testicular cancer...

Cryptorchidism is not a single disease; it apparently results from failure of one of at least two functions involving products of Leydig cells. Cryptorchidism is symptomatic of underlying testis dysgenesis. Precise terminology is important to distinguish and understand three phases of testis descent. Abdominal translocation involves holding a testis near the internal inguinal ring plus slight d...

The ultimate goal in the treatment of cryptorchidism is to achieve normal fertility. However, in a substantial number of cryptorchid males, early and apparently successful orchidopexy does not improve fertility as it does not address the underlying pathophysiological cause, namely, the impaired transformation of gonocytes into Ad spermatogonia. It is important to realize that over half the pati...

STUDY QUESTION Is there evidence at the population level of associations between different male genital disorders, outside Scandinavian countries? SUMMARY ANSWER At an international scale, there is evidence for a number of correlations between rates of four male reproductive disorders (hypospadias, cryptorchidism, testicular cancer and low sperm concentration). WHAT IS KNOWN ALREADY Some as...

Thank you Mr Chairmen for your kind introduction, and good afternoon, ladies and gentlemen. I’d like to thank the organisers for inviting me here, and for organising this excellent meeting. It is also a pleasure for me to pay a visit to Japan for the first time. The subject of my presentation is the prevalence of cryptorchidism and hypospadias, and the role of endocrine disrupters. I realise no...

Several clinicopathological illnesses impact the testis and paratesticular area, which are divided into non-neoplastic neoplastic diseases. Despite availability of imaging tumor marker testing, histopathological examination is primary method for diagnosing testicular lesions. Common indications orchidectomy lesions cryptorchidism, epididymitis torsion. Few non- present as mimickers neoplasm wit...