BACKGROUND Most studies have not demonstrated improved survival after prenatal diagnosis of critical congenital heart disease, including hypoplastic left heart syndrome (HLHS). However, the effect of delivery near a cardiac surgical center (CSC), the recommended action after prenatal diagnosis, on HLHS mortality has been poorly investigated. METHODS AND RESULTS Using Texas Birth Defects Regis...

The cancer stem cell (CSC) hypothesis states that only a small fraction of a malignant cell population is responsible for tumor growth and relapse. Understanding the relationships between CSC dynamics and cancer progression may contribute to improvements in cancer treatment. Analysis of a simple discrete mathematical model has suggested that homeostasis in developing tissues is governed by a "q...

Dendritic cell (DC)-based vaccines designed to target cancer stem cells (CSC) can induce significant antitumor responses via conferring host anti-CSC immunity. Our recent studies have demonstrated that CSC-DC vaccine could inhibit metastasis of primary tumors and induce humoral immune responses against cancer stem cells. This approach highlights the promise of cancer stem cell vaccine in cancer...

The successful 2d segmentation method CSC has recently been generalized to 3d. We shortly introduce the concept of both 2Dand 3D-CSC and present two use cases (classification of MR brain data and CT bone data) which demonstrate that analysis of segments generated by the CSC allows high quality classification of 3d data by relatively easy means.

The tumor growth paradox refers to the observation that incomplete treatment of cancers can enhance their growth. As shown here and elsewhere, the existence of cancer stem cells (CSC) can explain this effect. CSC are less sensitive to treatments, hence any stress applied to the tumor selects for CSC, thereby increasing the fitness of the tumor. In this paper we use a mathematical model to under...

Resistance to therapy is the main cause of tumor recurrence and metastasis and cancer stem cells (CSCs) play a crucial role in this process, especially in triple-negative breast cancers (TNBCs). Unfortunately, no FDA-approved treatment is currently available for this subtype of BC, which explains the high rate of mortality in patients with TNBC tumors. WAVE3, a member of the WASP/WAVE actin-cyt...

RATIONALE Cardiac stem cells (CSC) therapy has been clinically introduced for cardiac repair after myocardial infarction (MI). To date, there has been no systematic overview and meta-analysis of studies using CSC therapy for MI. OBJECTIVE Here, we used meta-analysis to establish the overall effect of CSCs in preclinical studies and assessed translational differences between and within large a...

The cancer stem cell (CSC) potency of a series structurally analogous Group 10-azadiphosphine metal complexes is reported. comprise 10 (Ni for 1, Pd 2, or Pt 3), an azadiphosphine ligand, and two chloride ligands. exhibit micromolar towards bulk breast cells CSCs cultured in monolayer systems. cytotoxicity the comparable to better than clinically used metallopharmaceuticals, cisplatin carboplat...

The Cubic Sieve Method for solving the Discrete Logarithm Problem in prime elds requires a nontrivial solution to the Cubic Sieve Congruence (CSC) x ≡ yz (mod p), where p is a given prime number. A nontrivial solution must also satisfy x 6= yz and 1 ≤ x , y, z < p, where α is a given real number such that 1 3 < α ≤ 1 2 . The CSC problem is to nd an e cient algorithm to obtain a nontrivial solut...

The aim of the study was to determine if the increase in radiopacity provided by bismuth oxide is related to the color alteration of calcium silicate-based cement. Calcium silicate cement (CSC) was mixed with 0%, 15%, 20%, 30% and 50% of bismuth oxide (BO), determined by weight. Mineral trioxide aggregate (MTA) was the control group. The radiopacity test was performed according to ISO 6876/2001...