BACKGROUND Cardiac troponins are markers for myocardial injury. Sepsis and septic shock can cause myocardial injury. The significance of elevated cardiac troponin T (cTnT) in septic shock was evaluated in the present study. MATERIAL AND METHOD Serum levels of cTnT were measured in 40 patients with septic shock from Rajavithi Hospital during a nine-month period between December 2004 and August...

INTRODUCTION Cardiac troponin T (cTnT) has been used to assess prevalence of myocardial injury in critically ill children. The majority of studies investigated patients undergoing cardiac surgery. Myocardial injury has been associated with increased mortality. Our objectives were to investigate whether cTnT levels are elevated in infants without congenital heart disease admitted to the paediatr...

BACKGROUND Reference intervals of high-sensitivity troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) have been determined from Western populations. No data are available regarding expected values in Asian populations. METHODS A total of 1157 age- and sex-matched healthy individuals (mean age, 41.2 years; 48.0% male) were prospectively enrolled from the US (n = 565...

BACKGROUND Serum cardiac troponin concentrations are commonly increased in end-stage renal disease (ESRD) in the absence of an acute coronary syndrome (ACS). The data on cardiac troponin I (cTnI) are more variable than those for cardiac troponin T (cTnT). There is little information on cardiac troponin concentrations in patients with chronic kidney disease (CKD) who have not commenced dialysis....

BACKGROUND Cardiac troponin T (cTnT) is the preferred biomarker for the diagnosis of acute myocardial infarction (AMI). It has been suggested that cTnT is present predominantly in fragmented forms in human serum following AMI. In this study, we have used a targeted mass spectrometry assay and epitope mapping using Western blotting to confirm this hypothesis. METHODS cTnT was captured from the...

PURPOSE Copeptin, a stable peptide derived from the AVP precursor, has been linked to presence and severity of myocardial ischemia. We sought to evaluate the predictive value of copeptin and its incremental value beyond that of high-sensitivity cardiac troponin T (hs-cTnT) in patients with acute chest pain and low to intermediate risk for acute coronary syndrome (ACS). METHODS We recruited pa...

OBJECTIVES The purpose of this study was to assess whether: 1) very small increases in troponin T, measured by a new highly sensitive cardiac troponin T (hs-cTnT), may reflect ischemia without necrosis; and 2) serial changes can discriminate ischemia from other causes of cardiac troponin T (cTnT) release. BACKGROUND A new hs-cTnT assay offers greater sensitivity than current assays. METHODS...

BACKGROUND This study determined the prevalence of increased cardiac troponin I (cTnI) and T (cTnT) in end-stage renal disease (ESRD) patients and whether an increased troponin was predictive of death. METHODS AND RESULTS Serum was obtained from 733 ESRD patients and measured for cTnI and cTnT. Relative risks were estimated using Cox proportional hazards regressions univariately and adjusted ...

Abstract Background Clinical practice and guidelines assume that cardiac troponin I (cTnI) cTnT are interchangeable, reflecting identical pathophysiological processes. However, it is unknown if cTnI really equivalent measures in different settings. Purpose To highlight potential differences the release of cTnT. Methods Large pooled cohort analysis including extensively characterized individuals...

OBJECTIVE To assess the effect of recalibration of the Roche 3rd-generation cTnT assay with recombinant human cardiac troponin T (cTnT) standards on clinical decision limits. MATERIALS AND METHODS Serum samples from 77 patients (66 +/- 16 years) admitted to the coronary care unit were assayed using the 2nd- and 3rd-generation cTnT assays. RESULTS There was excellent agreement (r = 0.99 Spea...