Original Article Sepsis SIRS (systemic inflammatory response syndrome), Bacteraemia Polymicrobial bacteraemia. Aims: The aim of this study was to identify clinical, laboratory and microbiologic features that may be predictive of mortality in sepsis and help achieve an early stratification to identify those at high risk of death in adult patients. Methods: A total of 298 adult patients with clin...

The aim of the present study was to investigate whether expression of monocyte and lymphocyte surface molecules differs between patients with severe sepsis and non-septic patients treated in the intensive care unit (ICU). The expression of monocyte CD14, CD40, CD80 and HLA-DR, and lymphocyte CD69 were analyzed using quantitative flow cytometry on three consecutive days in 27 patients with sever...

Epidemiology and surveillance of neonatal sepsis helps in implementation of rational empirical antibiotic strategy. The present study was conducted to record the frequency of bacterial isolates of neonatal sepsis and their sensitivity pattern in neonates treated in our tertiary care NICU. In this retrospective study, neonates in whom neonatal sepsis was suspected and blood culture done were inc...

Objectives: To determine the frequency of thrombocytopenia in culture-positive neonatal sepsis. Methodology: This hospital-based cross-sectional study was conducted at a tertiary care hospital Pakistan be­tween July to December 2021 Department Pediatrics, National Institue Child Health Karachi - Pakistan. All neonates admitted NICU with signs and symptoms sepsis positive blood culture were enro...

A Real-time polymerase chain reaction (PCR) with melting analysis was devised to target bacterial and fungal genes together with the most prevalent antimicrobial resistance genes in 250 positive blood culture broths. This method allowed the blood culture cultivated pathogens to be classified into clinically relevant groups such as Enterobacteriaceae, oxidase-positive bacilli, oxidase-positive c...

INTRODUCTION Sepsis is a major cause of significant morbidity and mortality in neutropenic patients. Blood culture remains the gold standard in the microbiological diagnosis of bacterial or fungal bloodstream infections, but it has clear limits of rapidity and sensitivity. The objective of the study was to compare the real-time polymerase chain reaction (RT-PCR) with automated blood cultures (B...

OBJECTIVES We determined whether initial antithrombin (AT) levels help in diagnosis and prognosis of neonatal sepsis. METHODS Sepsis was diagnosed according to clinical and laboratory findings and positive culture results in 34 of the 54 newborns who presented to the hospital with suspected sepsis. Between AT levels and hematological parameters (fibrinogen levels, prothrombin time (PT), activ...

Methods Prospective multicenter study of characteristics for repeated blood culture sampling in neonates admitted to three tertiary-referral intensive care units (period 7/201312/2014). Repeated blood culture samples were included when obtained within 14 days after the previous sample. Clinical sepsis is defined as the presence of 2 clinical signs and the duration of antibiotic therapy for ≥5 d...