AIC649 has been shown to directly address the antigen presenting cell arm of the host immune defense leading to a regulated cytokine release and activation of T cell responses. In the present study we analyzed the antiviral efficacy of AIC649 as well as its potential to induce functional cure in animal models for chronic hepatitis B. Hepatitis B virus transgenic mice and chronically woodchuck h...

This paper proposes, for the first time, use of an asymmetric positive and heavy-tailed distribution in a cure rate model context. In particular, it introduces cure-rate survival by assuming that time-to-event interest follows slash half-normal number competing causes event power series distribution, which defines six new models. Several properties are derived alternative expression cumulative ...

Several mathematical models have been proposed to describe the dynamics of irradiated cancer cells and to evaluate the tumour control probability (TCP). In this article, we propose a TCP model-based statistical test for predicting the outcome of a radiation treatment. We determine the foresight capability of prostate tumour erradication (cure) from Monte Carlo simulations of the Dawson-Hillen T...

  Abstract Introduction: One-bottle light-cured adhesives systems have variable pH. In addition to ease of use, universal adhesives can be used in various restorations and different substrates. Due to the lack of studies, the purpose of this study was to compare the enamel and dentin micro-leakage of self-cure and light cure composite restorations using a universal bonding system. Materials...

Introduction:One-bottle light-cured adhesives systems have variable pH. In addition to ease of use, universal adhesives can be used in various restorations and different substrates. Due to the lack of studies, the purpose of this study was to compare the enamel and dentin micro-leakage of self-cure and light cure composite restorations using a universal bonding system. Materials & Methods:The ...

The existence of immune or cured individuals in a population and whether there is sufficient follow-up sample censored observations on their lifetimes to be confident presence are questions major importance medical survival analysis. Here we give detailed analysis statistic designed test for sample. Assuming an i.i.d. censoring model, obtain exact finite-sample asymptotic distributions the stat...

BACKGROUND Many chronic pain patients (CPPs) cannot be cured of their pain, but can learn to manage it. This has led to research on pain "acceptance" which is defined as a behavior pattern with awareness of pain but not directed at changing pain. OBJECTIVE CPPs who have accepted their pain generally acknowledge that a cure is unlikely. Time with pain may be necessary to reach such an acknowle...