Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability, pacemaking, dendritic integration, and homeostatic plasticity and are culprits in aberrant neuronal activity in certain epilepsies. In this issue of Neuron two manuscripts (Santoro et al. and Zolles et al.) report that HCN channel gating and expression are controlled by Trip8b (Pex5R) but with a b...

This paper presents a method for implicit stress integration of the Drucker–Prager material model with kinematic hardening. The stress integration of the material model is conducted using the incremental plasticity method, while the kinematic hardening of material is defined using nonlinear Armstrong–Frederick hardening. This type of granular material hardening occurs as a consequence of the cy...

fiber metal laminates (fmls) are new composite materials consisting of thin metal layers and high strength composite layers. arall (aramid aluminum laminate) is a family of the fml that consists of thin aluminum sheets along with kevlar/epoxy composite layers. this material has many advantages such as light weight, excellent corrosion, fatigue and impact resistance. since, arall is a new materi...

Abstract. A comprehensive 3D visco-elasto-plasto-damage constitutive model of concrete is proposed to analyze its behaviour under long-term and cyclic loadings. This combines the visco-elasticy plasticity theories together with damage mechanics. The work aims at providing an efficient capable predicting material behaviour, taking into account time-dependent effects mesoscale. visco-elastic part...

Oxide scales that form on superalloys eventually spall, especially upon thermal cycling. This phenomenon is motivated by the large residual compression in the oxide. Buckling and interface crack propagation are known aspects of this behavior, but the origin of the interface separation that precedes and activates buckling is not understood. One mechanism is described and analyzed in this article...

Drastic changes in the environment during a lifetime require developmental and physiological flexibility to ensure animal survival. Desert locusts, Schistocerca gregaria, live in an extremely changeable environment, which alternates between periods of rainfall and abundant food and periods of drought and starvation. In order to survive, locusts display an extreme form of phenotypic plasticity t...