Synthetic atrial natriuretic factor (ANF) was either added to suffusate solutions (30 nM) or infused into the jugular vein (0.1 nanomol/min/100 g) of anesthetized rats. Steady-state blood flow was calculated from arteriolar diameter and red blood cell velocity measurements using video microscopy in the intestinal or skeletal muscle microcirculation. Arterioles demonstrated spontaneous vasomotor...

BACKGROUND AND AIMS Arachidonic acid metabolism actively participates in the initiation, climaxing, and resolution phases of inflammation, and its close connection with inflammatory bowel diseases has been only recently discovered. We aimed to clarify the role of different arachidonic pathways and the interrelationships between them in Crohn's disease. METHODS Seventeen specimens of Crohn's d...

BACKGROUND Cyclooxygenase-2 inhibitors inhibit bone repair. HYPOTHESIS Cyclooxygenase inhibitors might also have a negative effect on early tendon repair, although a positive effect on late tendon repair previously has been shown. STUDY DESIGN Controlled laboratory study. METHODS Achilles tendon transection was performed on 80 rats. Sixty rats were given daily intramuscular injections of ...

Recent scientific advancements have sparked an increasing trend of returning to nature. Scientists worldwide prefer natural medical derivatives over synthetic ones due fewer side effects. Green tea is abundant in bioactive components and vitamins. Although most green were thought be absorbed inadequately by oral administration, they are essential for better health. In the present study, silico ...

several studies point to an important function of cyclooxygenase (cox) and prostaglandin signaling in models of synaptic plasticity which is associated with n-methyl-d-aspartate receptors (nmdars). cyclooxygenase gene is suggested to be an immediate early gene that is tightly regulated in neurons by nmda dependent synaptic activity. nonsteroid antiinflammatory drugs (nsaids) exert their antiinf...

OBJECTIVE The purpose of this study was to determine whether cyclooxygenase inhibition improves vascular dysfunction of adipose microvessels from obese humans. DESIGN AND METHODS In 20 obese subjects (age 37 ± 12 years, BMI 47 ± 8 kg/m²), subcutaneous and visceral fat were collected during bariatric surgery and characterized for adipose depot-specific gene expression, endothelial cell phenoty...

Endothelial cells synthesize prostacyclin (PGI(2)), an unstable prostaglandin that inhibits platelet aggregation and serotonin release. Because cyclooxygenase, which is necessary for synthesis of PGI(2), is inactivated by aspirin, we examined the effect of aspirin on PGI(2) production by cultured human endothelial cells. Endothelial cells synthesize PGI(2) (20.1+/-7.2 ng/10(6) cells, mean+/-SD)...

Repeated hourly stimulation of perfused rabbit hydronephrotic kidney (HNK) with a fixed dose of bradykinin resulted in a progressive (to-fold in 6 h) increase in prostaglandin (PG) synthesis. Inhibition of protein synthesis with cycloheximide during perfusion abolished the enhanced time-dependent responsiveness of the HNK to peptide stimulation, whereas pretreatment of rabbits with aspirin, whi...