background: cytochrome p450 plays an important role in pharmaceutical metabolism, steroidal hormones and procarcinogens. cyp1a1 is an enzyme, which is very active in the formation of reactive mediators or injurious agents for dna. the aim of this study is to evaluate the prevalence rate of genetic polymorphism rs 1048943 gene cyp1a1 in men diagnosed with prostate cancer compared to a control gr...

vicia sativa l., an annual winter growing leguminous plant, is a valuable source of protein and minerals for cattle. drought is one of the key stress factors that influence plant growth and development. in order to investigate common vetch physiological and molecular responses under normal irrigation (n) and two levels of drought stress [s1= 30% and s2= 10% field capacity (fc)], a greenhouse exp...

Abstract: Although controversial, one of the puzzles in lung carcinogenesis is that women may be at a higher risk of lung cancer than men. The mechanisms underlying the sex differences in lung cancer susceptibility is likely to be multifactorial. Molecular studies have pointed to sex differences in the metabolism of polycyclic aromatic hydrocarbons (PAH). We have reported higher levels of PAH-D...

BACKGROUND Tobacco and alcohol contain or may generate carcinogenic compounds related to cancers. CYP1A1 enzymes act upon these carcinogens before elimination from the body. The aim of this study was to investigate whether CYP1A1 T3801C polymorphism modulates the relationship between tobacco and alcohol- associated head and neck cancer (HNC) susceptibility among the northeast Indian population....

Polymorphism of CYP2D6 gene encoding for debrisoquine hydroxylase was determined genotypically for 94 controls and 77 lung cancer patients using a polymerase chain reaction-based application. Both of the point mutations that give rise to deficient alleles of the CYP2D6 gene are detectable by this method. Out of the 94 healthy controls, 3 individuals (3.2%) had poor metabolizer (PM) genotypes, w...

BACKGROUND Ocean pollution affects marine organisms and ecosystems as well as humans. The International Oceanographic Commission recommends ocean health monitoring programs to investigate the presence of marine contaminants and the health of threatened species and the use of multiple and early-warning biomarker approaches. OBJECTIVE We explored the hypothesis that biomarker and contaminant an...

Objective: To estimate and compare the frequency of CYP1A1*2A gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to lung cancer risk. Methods: The study population included 200 patients with lung cancer, and the control group consisted of 264 blood donors. Genomic DNA was obtained from peripheral blood samples. The PCR-RFLP method wa...

Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). The expression of CYP1 (including CYP1A2 and CYP1B1) is considered to depend solely on a heterodimeric transcription factor consisting of the arylhydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT). So f...

Previous studies by us and others have shown a significantly higher level of aromatic DNA adducts in normal adjacent breast tissue samples obtained from breast cancer patients than in those obtained from non-cancerous controls. The increased amount of DNA damage could be related to excess environmental carcinogen exposure and/or genetic susceptibility to such exposure. In the current study, we ...

BACKGROUND Lung cancer is one of the most preventable causes of death globally both in developed and developing countries. Although it is well established that smokers develop lung cancer, there are some smokers who are free from the disease risk. The predisposition to lung cancer is attributed to genetic polymorphisms in xenobiotic metabolizing genes. Reports on assessment of xenobiotic metabo...